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Soluble microneedle having freckle-removing function and preparation method thereof

A micro-needle and functional technology, applied in skin care preparations, pharmaceutical formulations, drug devices, etc., can solve problems such as unsatisfactory effects of whitening products, and achieve the goal of improving cosmetic effects, improving transdermal absorption effects, and increasing absorption efficiency. Effect

Inactive Publication Date: 2019-06-07
广州纳丽生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the unsatisfactory effect of existing whitening products, an embodiment of the present invention provides a soluble microneedle with the function of removing freckles, including a base and a needle body on the base, and the needle body is embedded There is a compound antitranexamic acid composition, which includes the following components in weight percentage: tranexamic acid [A1]%, sodium ascorbyl phosphate 0.4-3.0%, hydroxycyclodextrin 3.0-12.0% , Maojian green tea extract 0.3-0.8%, hyaluronic acid 60-92%, the balance is water

Method used

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Examples

Experimental program
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Effect test

no. 1 example

[0020] An embodiment of the present invention provides a soluble microneedle with the function of removing freckles, including a base and a needle body on the base, the needle is embedded with a compound anti-tranexamic acid composition, and the compound anti-coagulant The acid composition includes the following components in weight percentage: 0.6-4.0% of tranexamic acid, 0.4-3.0% of sodium ascorbyl phosphate, 3.0-12.0% of hydroxycyclodextrin, 0.3-0.8% of Maojian green tea extract, and 60-92% of hyaluronic acid , and the balance is water.

[0021] As an improvement but not a limitation, the compound antitranexamic acid composition described above includes the following components in weight percentage: 1.0-3.0% of tranexamic acid, 0.6-2.4% of sodium ascorbyl phosphate, and 4.8-8.4% of hydroxycyclodextrin , Maojian green tea extract 0.4-0.7%, hyaluronic acid 80-92%, and the balance is water.

[0022] The above-mentioned soluble microneedles are in the shape of a truncated cone...

no. 2 example

[0025] An embodiment of the present invention provides a method for preparing a soluble microneedle with the function of removing freckles, the method comprising:

[0026] The preparation of compound antitranexamic acid composition:

[0027] Put sodium ascorbyl phosphate and hydroxycyclodextrin in water at a temperature of 20°C-40°C, stir until dissolved, and continue stirring for 0.5 hours to obtain the first stirred state solution;

[0028] Add water, Maojian green tea extract, and hyaluronic acid to the solution in the first stirring state in sequence, stir until dissolved, and continue stirring for 9-10 hours to obtain the second stirring state solution;

[0029] adding tranexamic acid into the solution in the second stirring state, continuing to stir for 0.5-2 hours, and filtering to obtain a compound antitranexamic acid composition;

[0030] Preparation of dissolvable microneedles:

[0031] The above-mentioned compound antitranexamic acid composition is injected into t...

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Abstract

The present invention discloses a soluble microneedle having a freckle-removing function. The soluble microneedle comprises a base seat and a needle body located on the base seat. The needle body is internally embedded with a compound anti-tranexamic acid composition. The compound anti-tranexamic acid composition comprises the following components in weight percentages: 0.6-4.0% of tranexamic acid, 0.4-3.0% of sodium ascorbyl phosphate, 3.0-12.0% of hydroxycyclodextrin, 0.3-0.8% of a Maojian green tea extract, 60-92% of hyaluronic acid and the balance water. The compound anti-tranexamic acid composition is embeded in the soluble microneedle needle body, direct supply of the composition to deep skin through skin stratum corneum is facilitated, and the soluble microneedle improves a transdermal absorption effect of the compound anti-tranexamic acid composition, increases absorption efficiency of the compound anti-tranexamic acid composition and further enhances freckle-fading time.

Description

technical field [0001] The invention relates to the technical fields of daily chemical industry and medicine, in particular to a soluble microneedle with the function of removing freckles and a preparation method thereof. Background technique [0002] Since the emergence of human civilization, there has been the pursuit of beautification. Oriental women yearn for and pursue healthy and fair skin. In ancient China, "everyone has the love of beauty", and in modern times, "one white covers three ugliness". aesthetics. The color of human skin is mainly determined by the quantity, size and distribution of melanin contained in skin cells. Melanin is a protein present in the basal layer of everyone's skin. The irradiation of ultraviolet rays will change the melanin to produce a substance that protects the skin, and then the melanin moves through the layers of cell metabolism to the epidermis of the skin, forming skin problems such as spots and uneven skin tone that we see. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/67A61K8/44A61K8/73A61K8/02A61Q19/02A61M37/00
Inventor 陈彦彪唐骢陈莉诗陈殿伟房俊英王锦涛
Owner 广州纳丽生物科技有限公司
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