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Compounds with antitumor activity isolated from Anemarrhena and its preparation method

A compound and a technology for preparing a column are applied in the field of compounds with anti-hepatoma activity, which can solve the problems of insufficient curative effect and normal cell death.

Active Publication Date: 2022-03-29
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapy is now the mainstay of treatment, but its non-selectivity also causes normal cell death
The existing chemical drugs for the treatment of hepatocellular carcinoma all have the defect that the curative effect is not significant enough. Isolating new compounds with significant anti-liver cancer activity from plants is of great significance for the treatment of liver cancer

Method used

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  • Compounds with antitumor activity isolated from Anemarrhena and its preparation method
  • Compounds with antitumor activity isolated from Anemarrhena and its preparation method
  • Compounds with antitumor activity isolated from Anemarrhena and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0064] Example 1 Separation, Preparation and Identification of Antitumor Compounds

[0065] The dried Anemarrhena fibrous roots (30kg) were pulverized and extracted by percolation with 70% ethanol. The ethanol percolate was concentrated under reduced pressure to obtain a brown crude extract. The crude extract was dispersed with water and extracted with ethyl acetate. Disperse the remaining water part after extraction with water, the solution flows through the AB-8 macroporous resin column, elutes with ethanol-water (10:90 and 90:10), and the 90% ethanol part passes through the silica gel column (200-300 mesh ) was further purified and eluted with dichloromethane-methanol (100:1~0:1) to obtain Fr.1~Fr.7. Fr.1 (dichloromethane-methanol=100:1 part) was subjected to silica gel column elution (gradient elution with petroleum ether-ethyl acetate system 20:1-1:1) to obtain Fr.1.1-Fr.1.4. Fr.1.3 (petroleum ether-ethyl acetate=5:1 fraction) obtained compound 4 (7mg, t R =20.3min, m...

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Abstract

The invention discloses a compound with antitumor activity isolated from Zhimu and a preparation method thereof. The invention separates and obtains the benzophenone compounds from the fibrous root of Zhimu. Antitumor activity tests in vitro show that the benzophenone compound has significant inhibitory activity on liver cancer cell lines. The present invention further provides an anti-tumor pharmaceutical composition, the pharmaceutical composition is composed of a therapeutically effective amount of the benzophenone compound with anti-tumor activity or a pharmaceutically acceptable salt thereof isolated from Anemarrhena anemarrhena Formed in coordination with pharmaceutically acceptable carriers.

Description

technical field [0001] The invention relates to a compound with anti-tumor activity isolated from plants, in particular to a compound with anti-liver cancer activity isolated from roots of Anemarrhena anemarrhena, belonging to the field of anti-cancer compounds. Background technique [0002] The traditional Chinese medicine Zhimu is the dry rhizome of Anemarrhena asphodeloides Bge., which is mainly distributed in China, Mongolia and other East Asian regions, and is widely used to treat various diseases, such as fever and diabetes. As a non-medicinal part, Anemarrhena fibrous roots are often discarded in large quantities during the processing of Anemarrhena, which not only causes waste of resources, but also aggravates environmental pollution. The chemical composition and pharmacological effects of Anemarrhena fibrous roots are basically the same as Anemarrhena. Therefore, it is necessary to develop and utilize Anemarrhena fibrous root resources. [0003] Hepatocellular car...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H19/01C07H1/08C07D207/267C07C69/738C07C67/48C07C67/56C07C49/83C07C45/78C07C45/79A61P35/00A61P1/16A61K31/7048A61K31/4015A61K31/216A61K31/12
Inventor 吴德玲廖振东黄琪张伟许凤清
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE