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A device and method for microfluidic transport on a piezoelectric substrate

A piezoelectric substrate, microfluidic technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of decreased biomolecular activity and increased temperature of microfluidics

Inactive Publication Date: 2021-06-15
武夷学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a device and method for transporting microfluids on piezoelectric substrates controlled by surface acoustic waves, which avoids the direct radiation of surface acoustic waves into microfluids, and not only solves the problems caused by the temperature rise of microfluids The problem of evaporation, but also solves the problem of decreased activity of biomolecules

Method used

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  • A device and method for microfluidic transport on a piezoelectric substrate
  • A device and method for microfluidic transport on a piezoelectric substrate

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Embodiment 1

[0023] A device for transporting microfluids on a piezoelectric substrate proposed in this embodiment includes a piezoelectric substrate 1, a signal generating device 2 for generating RF electrical signals, a PCB board 3, and the upper surface of the piezoelectric substrate 1 As the working surface, an unweighted interdigital transducer 4 for exciting surface acoustic waves is arranged on the periphery of the working surface of the piezoelectric substrate 1, and the unweighted interdigital transducer 4 is arranged on the working surface of the piezoelectric substrate 1 with the unweighted interdigital transducer 4. Correspondingly, the transducer 4 is provided with a reflection grid 5, the reflection grid 5 is used to reduce the power of the RF electrical signal loaded on the unweighted interdigital transducer 4, and the working surface of the piezoelectric substrate 1 is located on the unweighted interdigital transducer 4. On the propagation path of the surface acoustic wave e...

Embodiment 2

[0025] The device for transporting microfluids on a piezoelectric substrate proposed in this embodiment is further improved on the basis of the device in Embodiment 1, that is, PDMS coagulation layers are arranged on both sides of the symmetrical surface of the middle part of the microsphere bead 7. Layer 8, the PDMS coagulation layer 8 protrudes from the surface of the microsphere beads 7 by 0.2 mm to 0.5 mm (such as 0.4 mm), and the width of the PDMS coagulation layer 8 along the circumference of the microsphere beads 7 is 0.2 mm to 0.5 mm (such as 0.5 mm). ), the upper surface of the PDMS solidified layer 8 is used as the second liquid storage area 81 for storing the aqueous microfluid 9 to be transported. The PDMS coagulation layer 8 is arranged on both sides of the symmetrical surface of the middle part of the microsphere bead 7, which can ensure that the microsphere bead 7 is stressed symmetrically; The second liquid storage area 81, that is, under the premise of setting...

Embodiment 3

[0027] A device for transporting microfluids on a piezoelectric substrate proposed in this embodiment is basically the same in structure as that of the device in Embodiment 1 or Embodiment 2, the only difference being that the device of this embodiment is in the piezoelectric substrate 1 Unweighted interdigital transducers 4 are arranged at different positions around the working surface of the working surface, that is, a plurality of unweighted interdigital transducers 4 are arranged, and the unweighted interdigital transducers 4 at different positions are configured by a switching switch 23 4 is loaded with an RF electric signal, and the aqueous solution microfluid 9 to be transported stored on the first liquid storage area 71 or the second liquid storage area 81 can be transported at any position in the two-dimensional plane of the working surface of the piezoelectric substrate 1. transport.

[0028] As mentioned above, the piezoelectric substrate 1 can adopt a piezoelectric...

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Abstract

The invention discloses a device and method for transporting microfluid on a piezoelectric substrate. On the working surface of the electric substrate and on the propagation path of the surface acoustic wave excited by one of the unweighted interdigital transducers, paraffin oil is dropped, and microsphere beads are placed on the paraffin oil, and the upper hemispherical surface of the microsphere beads is used as a In the first liquid storage area of ​​the aqueous microfluid to be transported; the unweighted interdigital transducer corresponding to the paraffin oil excites the surface acoustic wave after the RF electric signal is loaded, and the surface acoustic wave radiates into the paraffin oil to drive the paraffin oil Drive the microspheres to slide along the propagation path of the surface acoustic wave to realize the transportation of the aqueous solution microfluid stored in the first liquid storage area; the advantage is that it avoids the direct radiation of the surface acoustic wave into the aqueous solution microfluid, and solves the problem of the temperature of the microfluid Elevation causes problems with evaporation and decreased activity of biomolecules.

Description

technical field [0001] The invention relates to a microfluid transportation technology in a microfluidic chip, in particular to a device and method for microfluid transportation on a piezoelectric substrate. Background technique [0002] Since Kilby invented the integrated circuit in 1958, miniaturization has become an important research topic of various electronic or non-electronic devices, among which the miniaturization of non-electronic devices is the most typical micromechanical system (MEMS). With the rapid development of micromechanical systems, they have widely penetrated into various fields of scientific research, especially biochemical analysis systems. The organic combination of micro-mechanical systems and biochemical analysis has promoted the emergence, development and wide application of total micro-analysis systems. Compared with traditional laboratory analysis, the full micro-analysis system has the advantages of small volume, less reagent consumption, and a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
Inventor 章安良
Owner 武夷学院
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