Preparation method and application of cold cough relieving granules

Abstract

The invention discloses a preparation method and application of cold cough relieving granules. The cold cough relieving granules are prepared from 100 g of radix bupleuri, 75 g of lonicerae flos, 100g of kudzuvine roots, 75 g of artemisia apiacea , 75 g of fructus forsythiae, 75 g of scutellaria baicalensis, 50 g of platycodon grandiflorum, 50 g of semen armeniacae amarae and 0.15 g of menthol through supercritical extraction, microwave extraction and microporous membrane filtration, and the content of effective components is greatly improved. The invention further provides the application of the cold cough relieving granules in preparation of medicines for inhibiting human lymphoma cell U-937 cell proliferation.

Description

technical field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method and application of Ganmaozhike Granules. Background technique

[0002] Ganmao Zhike Granules are recorded on page 1643 of the first part of the 2015 edition of the Pharmacopoeia of the People's Republic of China. It consists of 100g of Bupleurum bupleuri, 75g of mountain silver flower, 100g of kudzu root, 75g of Artemisia annua, 75g of forsythia, 75g of skullcap, 50g of platycodon, bitter 50g of almonds and 0.15g of menthol are prepared as raw materials. The above nine flavors, except menthol, the other eight flavors such as Bupleurum, decoct twice with water, filter the decoction for 4 hours each time, combine the filtrate, concentrate to an appropriate amount, add sucrose and dextrin, make granules, dry, Dissolve menthol with ethanol in an appropriate amount, spray it into the granules, mix well, and make 1000g; or spray-dry the conce...