Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of cold cough relieving granules

A technology for relieving cough and granules for colds, which is applied in the field of preparation of granules for relieving colds and coughs, can solve the problems of low extraction rate, rough process, easy dissipation of volatile components of medicines, etc., and achieves the effect of reducing dosage

Inactive Publication Date: 2019-06-28
广东恒诚制药股份有限公司
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Ganmaozhike Granules. However, the method of distillation and decoction is rough and backward, with many impurities and low extraction rate. The boiling point and low volatility components are all extracted, and under high temperature for a long time, the volatile components of the drug are easy to escape, and some pyrolyzable substances or chemically unstable components are also easily destroyed. The loss is huge, seriously affecting the efficacy of the drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take honeysuckle, kudzu root, and scutellaria baicalensis and add them to a CO2 supercritical extractor. Ethanol is used as an entrainer. The volume percentage of the entrainer in the total extraction solvent is 3%. The isothermal positive pressure method is used for extraction. The first extraction pressure is 10MPa, and the extraction time is 45min, second extraction pressure 20Mpa, extraction time 45min, third extraction pressure 40Mpa, extraction time 30min, temperature 40°C, CO 2 The flow rate is 1m1 / g crude drug·min to obtain supercritical extract, which is used for later use; take Artemisia annua, Forsythia, Platycodon grandiflorum, grind them, add 2L of 70% ethanol, put them into a microwave extraction device for microwave extraction, extraction power is 500W, and extract twice , 10 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 8 times the column volume eluate, recover ethano...

Embodiment 2

[0035] Take honeysuckle, kudzu root, and skullcap and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 5%. The isothermal positive pressure method is used for extraction. The first extraction pressure is 20MPa, the extraction time is 75min, and the second extraction pressure is 30Mpa. The extraction time is 75min, the third extraction pressure is 50Mpa, the extraction time is 60min, the temperature is 50℃, CO 2 The flow rate is 3m1 / g crude drug·min to obtain supercritical extracts for later use; take Artemisia annua, Forsythia, and Campanulaceae, crush them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction, extraction power 500W, extraction 2 times , 15 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 8 times the column volume eluate, re...

Embodiment 3

[0038] Take honeysuckle, kudzu root, and skullcap and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%. The isothermal positive pressure method is used for extraction. The first extraction pressure is 15MPa, the extraction time is 60min, and the second extraction pressure is 25Mpa. The extraction time is 60min, the third extraction pressure is 45Mpa, the extraction time is 45min, the temperature is 45°C, CO 2 The flow rate is 2m1 / g crude drug min, to obtain supercritical extract, and set aside; take Artemisia annua, Forsythia, Platycodon grandiflorum, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction, extraction power 500W, extraction 2 times , 10 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 8 times the column volume el...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method and application of cold cough relieving granules. The cold cough relieving granules are prepared from 100 g of radix bupleuri, 75 g of lonicerae flos, 100g of kudzuvine roots, 75 g of artemisia apiacea , 75 g of fructus forsythiae, 75 g of scutellaria baicalensis, 50 g of platycodon grandiflorum, 50 g of semen armeniacae amarae and 0.15 g of menthol through supercritical extraction, microwave extraction and microporous membrane filtration, and the content of effective components is greatly improved. The invention further provides the application of the cold cough relieving granules in preparation of medicines for inhibiting human lymphoma cell U-937 cell proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method and application of Ganmaozhike Granules. Background technique [0002] Ganmao Zhike Granules are recorded on page 1643 of the first part of the 2015 edition of the Pharmacopoeia of the People's Republic of China. It consists of 100g of Bupleurum bupleuri, 75g of mountain silver flower, 100g of kudzu root, 75g of Artemisia annua, 75g of forsythia, 75g of skullcap, 50g of platycodon, bitter 50g of almonds and 0.15g of menthol are prepared as raw materials. The above nine flavors, except menthol, the other eight flavors such as Bupleurum, decoct twice with water, filter the decoction for 4 hours each time, combine the filtrate, concentrate to an appropriate amount, add sucrose and dextrin, make granules, dry, Dissolve menthol with ethanol in an appropriate amount, spray it into the granules, mix well, and make 1000g; or spray-dry the conce...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/736A61K9/16A61P11/00A61P11/14A61P35/00A61K31/045
Inventor 张志涛符正南周文双陈雨汤小燕李智洋
Owner 广东恒诚制药股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com