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A kind of photocured medical catheter hydrophilic lubricating coating and preparation method thereof

一种润滑涂层、医用导管的技术，应用在导管、涂层、医药配方等方向，达到涂层工艺简单易控制、附着力和紫外光固化速度提高、避免化学反应的效果

Active Publication Date: 2022-07-15
ORBUSNEICH MEDICAL SHENZHEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The technical problem to be solved by the present invention is to provide a light-cured medical catheter hydrophilic lubricating coating and its preparation method according to the current state of the art, which solves the problems of adhesion, lubricity, durability, rapid curing, etc. Problem, the fast-curing hydrophilic coating endows medical catheters with good hydrophilic properties, good adhesion, and long-lasting lubricity

Method used

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  • A kind of photocured medical catheter hydrophilic lubricating coating and preparation method thereof
  • A kind of photocured medical catheter hydrophilic lubricating coating and preparation method thereof
  • A kind of photocured medical catheter hydrophilic lubricating coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Bottom coating configuration: weighing 2.0g of 6-functional polyester acrylic resin, 0.4g of hydroxyethyl methacrylate, 0.15g of polyether modified organosiloxane, photoinitiator 2-hydroxy-2-methylpropiophenone 0.3g, 24g of absolute ethanol, placed in a brown bottle, magnetically stirred for 2h, filtered through a 500-mesh nylon gauze, to obtain a mixed solution of the bottom coating.

[0056] Lubricating coating configuration: weigh 1.0g of polyvinylpyrrolidone, 0.4g of polyvinyl pyridine substances, 0.2g of polyethylene glycol, 0.1g of polyethylene oxide, 12g of water, and 31.3g of anhydrous ethanol, placed in a brown bottle, Magnetic stirring for 1-3 hours, filtered through a 500-mesh nylon gauze, to obtain a mixed solution of lubricating coating.

Embodiment 2

[0058] Primer coating configuration: Weigh 3-functional polyester acrylic resin 1.0g, 6-functional polyester acrylic resin 1.0g, hydroxyethyl methacrylate 0.4g, polyether modified organosiloxane 0.15g, photoinitiator 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (IRGACURE 2959) 0.3g, absolute ethanol 24g, placed in a brown bottle, magnetically stirred for 2h, filtered through 500-mesh nylon gauze Filtration to obtain a mixed solution of the bottom coating layer.

[0059] Lubricating coating configuration: weigh 1.0g of polyvinylpyrrolidone, 0.4g of polyvinyl pyridine, 0.2g of polyethylene glycol, 12g of water, and 31.3g of anhydrous ethanol, placed in a brown bottle, magnetically stirred for 1-3h, Filter through a 500-mesh nylon gauze to obtain a mixed solution of lubricating coating.

Embodiment 3

[0061] Primer coating configuration: weigh 1.0g of 3-functional polyester acrylic resin, 0.4 g of 6-functional polyester acrylic resin, 0.6 g of vinylpyrrolidone, 0.15 g of polyether-modified organosiloxane, and 2-hydroxyl photoinitiator -4'-(2-hydroxyethoxy)-2-methylpropiophenone (IRGACURE 2959) 0.3g, absolute ethanol 24g, placed in a brown bottle, magnetically stirred for 2h, filtered through 500-mesh nylon gauze to obtain Base coat mix solution.

[0062] Lubricating coating configuration: weigh 1.0g of polyvinylpyrrolidone, 0.4g of polyvinylpyridine, 8.4g of water, and 31.3g of anhydrous ethanol, placed in a brown bottle, magnetically stirred for 1-3h, and passed through a 500-mesh nylon gauze Filtration to obtain a mixed solution of lubricating coating.

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Abstract

The invention discloses a light-cured hydrophilic lubricating coating for medical catheters and a preparation method thereof. The hydrophilic lubricating coating comprises a primer coating attached to the surface of the device and a lubricating coating attached to the underlying coating. The base coat includes: 1-10 parts of polyester acrylate, 50-90 parts of solvent, 0.5-5 parts of photoinitiator, 0.5-2 parts of wetting agent and 0.5-5 parts of reactive diluent; lubricating coating includes: water-soluble 1-10 parts of macromolecules, 1-5 parts of cross-linking macromolecules, 0-1 parts of photoinitiator, 0.1-1 parts of surfactant, and 50-98 parts of mixed solvent. The preparation method of the hydrophilic lubricating coating of the invention is simple and easy to operate, and avoids the residue of substances caused by complex high-temperature chemical reactions; the cured coating forms a cross-linked structure, which not only has good adhesion on the surface of medical catheters, but also has excellent performance in aqueous media. And the long-lasting lubricity reduces the friction coefficient on the surface of the medical catheter, reduces the damage to human tissue and the adhesion of macromolecules in the blood.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a light-cured hydrophilic lubricating coating for medical catheters and a preparation method thereof. Background technique [0002] Interventional therapy catheters are widely used in clinical treatment. Many short-term or long-term devices that are in contact with human tissue, such as balloon catheters, guide catheters, and guide wires, will rub against the contacted tissue when inserted or pulled out, causing the device It is difficult to access the designated lesion site, which is not conducive to the surgical operation, and may cause adverse reactions such as tissue damage and inflammation. In order to reduce the risk of surgery and relieve the pain of patients, people have successively developed various lubricating coatings for medical catheters. In recent years, the research focus has shifted to hydrophilic lubricating coatings with water solubility and biocompati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/08A61L29/14A61L29/18
CPCA61L29/085A61L29/08A61L29/14A61L29/18A61L2400/18A61L2420/02A61L2420/08A61L2420/06C08L67/06C08L39/06C08L29/04C08L71/02A61L2400/10B05D5/08B05D7/542B05D3/067B05D2201/00B05D2254/02C10N2040/50C10N2050/023B05D3/10C10M107/32C10M107/34C10M107/42C10M155/02C10M169/041C10M2209/1023C10M2209/1045C10M2217/0285C10M2229/02
Inventor 朱靖静徐松云李勉彭畅龚伊容
Owner ORBUSNEICH MEDICAL SHENZHEN CO LTD
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