Preparation method of ZIF-8/Au compound surface enhanced Raman substrate

A technology of surface-enhanced Raman and ZIF-8, which is applied in nanotechnology, Raman scattering, metal processing equipment, etc. for materials and surface science, can solve problems affecting the repeatability of SERS signals, and avoid variability , Strong spectral enhancement effect

Inactive Publication Date: 2019-07-05
BEIJING INFORMATION SCI & TECH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional SERS-based sensors often rely on the aggregation of nanoparticles, and the variability of nanoparticle aggregation affects the reproducibility of SERS signals.

Method used

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  • Preparation method of ZIF-8/Au compound surface enhanced Raman substrate
  • Preparation method of ZIF-8/Au compound surface enhanced Raman substrate
  • Preparation method of ZIF-8/Au compound surface enhanced Raman substrate

Examples

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preparation example Construction

[0018] A method for preparing a ZIF-8 / Au composite surface enhanced Raman substrate, comprising the following steps:

[0019] Step 1. Add 50ml of ultrapure water to a 100ml round-bottom beaker, pipette 0.5ml of 1% chloroauric acid aqueous solution into the ultrapure water with a cleaned 1ml pipette, so that the concentration of chloroauric acid in the solution Reduced to 0.01%;

[0020] Step 2, using an oil bath to heat the obtained solution and keep the temperature at 88-96°C;

[0021] Step 3, using magnets to stir the constant temperature solution, during the stirring process, quickly add 0.25 ~ 4ml of trisodium citrate solution with a concentration of 1%, and continue stirring for 20 minutes to obtain gold nanoparticles with a particle size of 40-60nm;

[0022] Step 4, dissolve the nano-gold obtained in step 3 in 5ml deionized water to form a nano-gold aqueous solution, which is set aside;

[0023] Step 5, 1.17 g Zn(NO3)2•6H2O was dissolved in 7 g deionized water, and the...

Embodiment 1

[0028] Add 50ml of ultrapure water into a 100ml round bottom beaker, pipette 0.5ml of 1% chloroauric acid aqueous solution into the ultrapure water with a cleaned 1ml pipette, so that the concentration of chloroauric acid in the solution is reduced to 0.01 %; use an oil bath to heat the obtained solution and keep the constant temperature at 90°C; use a magnet to stir the constant temperature solution, add 0.5ml of trisodium citrate solution with a concentration of 1% quickly during the stirring process, and continue stirring for 20 minutes to obtain granules diameter is 40-60nm nano-gold; the gained nano-gold is dissolved in 5ml deionized water to form a nano-gold aqueous solution for subsequent use; 1.17 g Zn(NO3) 2·6H2O is dissolved in 7 g deionized water, and then 1ml nano-gold is added Aqueous solution; 22.70 g 2-methylimidazole was dissolved in 80 g deionized water; Zn(NO3)2·6H2O and nano-gold mixed solution was mixed with 2-methylimidazole solution, stirred for 5 minutes,...

Embodiment 2

[0030] The following is an experiment using the ZIF-8 / Au composite surface-enhanced Raman substrate prepared in Example 1.

[0031] Experiment 1: 4-mercaptopyridine (4-MPy) was selected as the test object, and 4-mercaptopyridine (4-MPy ) of the SERS plot, such as figure 1 shown.

[0032] Experiment 2: The selected concentrations were 10 -3 M, 10 -4 M, 10 -5 M, 10 -6 M, 10 -7 M, 10 -8 M's 4-mercaptopyridine (4-MPy) was used as a test substance, and the ZIF-8 / Au complex surface-enhanced Raman substrate prepared in Example 1 was used to detect various test substances, and different concentrations of 4-mercaptopyridine (4-MPy) were obtained. MPy) under the SERS diagram, such as figure 2 shown.

[0033] It can be seen from the above experiments that the Raman enhancement effect of the surface-enhanced Raman substrate of the ZIF-8 / Au composite is significantly improved, and the Au in the composite has a Raman enhancement effect on ZIF-8.

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Abstract

The invention discloses a preparation method of a ZIF-8/Au compound surface enhanced Raman substrate. The method comprises the steps that nano gold is prepared; the nano gold with the particle diameter of 40-60 nm is selected to dissolved in 5 ml of deionized water to form a nano gold aqueous solution for later use; 1.17 g of Zn(NO3)2-6H2O is dissolved in 7 g of deionized water, 1 ml of the nano gold aqueous solution is added; 22.70 g of 2-methylimidazole is dissolved in 80 g of deionized water; a 2-methylimidazole solution is stirred and mixed with a Zn(NO3)2-6H2O and nano gold mixed solution, stirring is conducted for 5 minutes, and precipitants are collected after centrifugation; the precipitants are repeatedly flushed by using the deionized water for two times, and powder shape ZIF-8/Au compound surface enhanced Raman substrate is obtained after drying. The ZIF-8/Au compound surface enhanced Raman substrate has the advantages that the clearance between the nano gold particle is ensured, the variability of nano particle aggregation is avoided, and therefore stronger spectral enhancement effect in measuring is achieved.

Description

technical field [0001] The invention relates to the technical field of Raman detection, in particular to a method for preparing a ZIF-8 / Au composite surface-enhanced Raman substrate. Background technique [0002] Surface-enhanced Raman scattering (SERS), as a high-resolution fingerprint, has been widely used in the field of biomedical detection. However, traditional SERS-based sensors often rely on the aggregation of nanoparticles, and the variability of nanoparticle aggregation affects the reproducibility of SERS signals. Therefore, appropriate methods must be taken to limit the aggregation of nanoparticles to ensure the ideal enhancement effect. Zn-ion-based metal-organic frameworks (ZIF-8) contain regular pores and channels that allow molecular access, and the hybrid framework structure has greater flexibility in surface modification. Compared with other metal-organic framework materials, ZIF-8 exhibits better hydrothermal and chemical stability, and is an ideal surfa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00G01N21/65
CPCB22F9/24B82Y30/00G01N21/658B22F2009/245B22F1/054B22F1/10
Inventor 朱桂贤祝连庆娄小平张健姚齐峰何巍董明利
Owner BEIJING INFORMATION SCI & TECH UNIV
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