Purification method of haloperidol

A technology of haloperidol and a purification method, applied in the direction of organic chemistry, which can solve the problems of difficult removal of dimerization impurities and inability to obtain active drug molecules with qualified purity, and achieve the effect of high product yield
CN109970624BActive Publication Date: 2020-05-22SHANGHAI XUDONG HAIPU PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI XUDONG HAIPU PHARMA
Publication Date
2020-05-22

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Abstract

A method for purifying haloperidol, first dissolving the prepared crude haloperidol in hot DMSO solution, filtering to remove dimer impurities insoluble in DMSO, and obtaining haloperidol with qualified dimer impurity content alcohol. In the method for purifying haloperidol provided by the present invention, the crude product of haloperidol is added into a hot DMSO solution to efficiently remove the dimerized impurities generated during the synthesis, so that the dimerized impurities of the obtained haloperidol The content is less than 0.05w / w%.
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Description

technical field

[0001] The invention relates to a method for preparing butyrophenone compounds, in particular to a method for purifying haloperidol, which improves the purity of the product. Background technique

[0002] Haloperidol acute and chronic schizophrenia and mania. Intramuscular injection of this product can quickly control agitation, hostility and aggressive behavior, and can also be used for brain organic mental disorders and senile mental disorders.

[0003] Synthetic process route is shown in following formula I:

[0004]

[0005] The second step reaction of this route is easy to produce multiple impurities, especially dimeric impurities are difficult to remove, and active drug molecules with qualified purity cannot be obtained, as shown in the following formula II:

[0006]

[0007] The commonly used refining method is to remove the impurity by dissolving in an organic solvent and then crystallizing. Contents of the invention

[0008] The object of ...

Claims

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