Treatment agent applied to prevention and/or treatment of foot diseases in diabetes
A technology of glycosides and solvates, which is applied in the field of therapeutic agents containing glycosides, can solve the problems of incompletely clear detailed mechanism and the like
Active Publication Date: 2019-07-09
HEHUANG PHARMA SHANGHAI
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- Description
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Problems solved by technology
However, the detailed mechanism is still unclear
Method used
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preparation example Construction
[0570] The preparation method of TG-047 refers to the preparation method of TG-048, and its structure is as follows:
[0571]
[0572] TG-047 identification data
[0573] 1H NMR (400MHz, CD3OD) δ7.18(d, J=8.6Hz, 2H), 6.85(d, J=8.6Hz, 2H), 4.38(d, J=9.5Hz, 1H), 3.90(dd, J =12.0,1.8Hz,1H),3.78(s,3H),3.69(dd,J=12.0,5.4Hz,1H),3.36-3.26(m,3H),3.22(t,J=8.7Hz,1H) ,3.07-2.86(m,4H).
[0574] LRMS (ESI): [M+COOH] -375.0.
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The invention relates to a glycoside compound shown in a formula III and application of salt of the compound in preparation of a medicine composition. The glycoside compound can be applied to prevention and / or treatment of ischemic diseases, particularly foot gangrene in foot gangrene.
Description
technical field [0001] The invention relates to a therapeutic agent containing a glycoside compound, which is used for preventing and / or treating lower limb ischemic microcirculation disorder. Background technique [0002] Diabetic foot gangrene (DF for short) is the most common ischemic microcirculation disorder of the lower extremities. It is a chronic disease of extremity gangrene caused by the stenosis and blockage of the arterial lumen due to the long-term high blood sugar and lipid metabolism disorder in diabetic patients. . The main clinical manifestations are numbness in hands and feet, extremity ischemia, infection, suppuration, and ulceration. If the blood vessel cavity is narrowed or blocked in diabetic patients, peripheral nerve damage and peripheral vascular disease are prone to occur, insufficient blood supply to the extremities, heavy load on the foot, and easy injury. It is easy to cause microbial invasion and infection, and the high-sugar environment of di...
Claims
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IPC IPC(8): C07H15/18C07H15/26C07H15/04C07H1/00A61P9/00A61P9/10C07C69/16C07C43/23
CPCA61P9/00A61P9/10A61K31/7034C07C43/23C07C69/16C07H1/00C07H15/18C07H15/26A61K45/06C07H5/10
Inventor 张建革林国强田平冯陈国詹常森周俊杰
Owner HEHUANG PHARMA SHANGHAI
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