Preparation method of animal skin acellular matrix dressing and dressing obtained

An acellular matrix and decellularization technology, which is applied in the preparation of animal skin acellular matrix dressings, and in the field of acellular matrix dressings, can solve the adverse effects on the structure and performance of collagen fibers in the acellular dermal matrix, and the removal of DNA/RNA has not attracted enough attention , easy to produce immune rejection and other problems, to achieve the effect of allowing cell repopulation, reducing the risk of transmission, and completely removing antigens
CN107397972AInactive Publication Date: 2017-11-28BEIJING NATON TECH GRP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING NATON TECH GRP CO LTD
Publication Date
2017-11-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of animal skin acellular matrix dressing. The preparation method comprises the following steps: a step of inactivation of virus, a degreasing step, an unhairing step and a decellularizing step on split-thickness skin of animal skin, wherein the decellularizing step comprises multiple freeze thawing steps and a decellularizing step by a decellularizing solution after the multiple freeze thawing steps. The invention also provides the animal skin acellular matrix dressing prepared by the preparation method. By means of a decellularizing step combining a physical method and a chemical method, netty structures of elastic fibers and collagens of an extracellular matrix are retained to the maximum extent, and meanwhile, antigens are thoroughly removed. The acellular dermal matrix dressing obtained by the preparation method is permeable and ventilating, can provide a moist micro-environment for the wound, remarkably reduces the rejection reaction of heterogeneity, allows reproliferation of cells, shortens the healing time, reduces cicatricial formation, is convenient to apply, and can be applied to the fields of burn and scale treatment, chronic wound healing, diabetic foot treatment and the like.
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Description

technical field

[0001] The invention relates to the field of biomedical materials, in particular to a preparation method of an animal skin acellular matrix dressing and the obtained acellular matrix dressing. Background technique

[0002] The healing and wound repair of chronic wounds such as burns, wounds, bedsores, diabetic feet, and lower extremity ulcers has always been a major clinical problem. At present, the high-end wet dressings commonly used in the market include hydrocolloid and alginate filling dressings. The disadvantage of hydrocolloid dressings is that they are not suitable for wounds with a lot of exudate and wounds with dead space or depth; the disadvantage of alginate filling dressings is that they are not suitable for dry scab wounds.

[0003] A good wound covering can create a microenvironment suitable for tissue repair. Therefore, researchers have been seeking a better wound dressing in recent years. In 1985, Heck et al. reported in The Journal of Tra...

Claims

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