Modularly designed piezoelectric ultrasonic microinjection device adaptive to needles of multiple types

Abstract

The invention discloses a modularly designed piezoelectric ultrasonic microinjection device adaptive to needles of multiple types. The microinjection device includes a connection rod, a piezoelectricdrive module, a shell, a flexible mechanism and a plurality of base modules, wherein the connection rod is used for connection, the piezoelectric drive module is used for providing movement, the shellis connected with the connection rod and is used for providing a containing space, the flexible mechanism is connected with the piezoelectric drive module and is used for transmitting movement generated by the piezoelectric drive module, the base modules are replaceably connected with the flexible mechanism and are used for fixing the injection needles, and different base modules are adaptive tothe needles of different types. According to the modularly designed piezoelectric ultrasonic microinjection device adaptive to the needles of multiple types, replaceable base module design is adopted,and therefore the modularly designed piezoelectric ultrasonic microinjection device can not only inhibit harmful transverse vibration during injection but also be compatible with the injection needles of different types.

Description

technical field [0001] The invention relates to the technical field of biomedical-related surgical devices, in particular to a piezoelectric ultrasonic microinjection device with a modular design and adapted to multiple types of needles. Background technique [0002] With the rapid development of modern biomedicine, the application of biological cell microinjection is becoming more and more popular, such as genetically modified organisms, artificial assisted reproduction, biopharmaceuticals and cloning technology, etc. Microinjection is divided into three processes: membrane rupture, injection and needle withdrawal. In the process of membrane rupture, since the operated object (eg. egg cell) is a fragile viscoelastic body, the method of direct insertion of the injection needle will cause huge deformation of the cell, which will easily cause damage to the cytoskeleton and internal structure, resulting in the Cell viability is low. The scientific research community has done ...

AI Technical Summary

Problems solved by technology

[0004] Although the prior art has made many improvements to the microinjection device, the microdevices in the prior art are only designed for one type of injection needle (straight needle or curved needle), and different injection needles (straight needle or curved needle) Needles) are applicable to different fields and scopes, therefore, if different microinjection experiments are performed, the entire microinjection device needs to be replaced, which increases the cost and increases the difficulty of use

Furthermore, the design of the microinjection device in the prior art is too complicated and integrated, not only the processing and assembly is difficult, the processing cost is high, but also the service life of piezoelectric ceramics is limited, which is not conducive to later maintenance

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