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Preparation method of 2-methylaziridine

A technology of methylaziridine and isopropanolamine, which is applied in the field of preparation of 2-methylaziridine, can solve the problems of large environmental hazards, low synthesis efficiency, and many by-products, and achieve less by-products and better synthesis The effect of mild conditions and simple synthetic raw materials

Pending Publication Date: 2019-07-12
NINGXIA JOIE MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 2-methyl aziridine is a kind of important pharmaceutical intermediate, has extensive application in many fields, there are many kinds of synthetic techniques of 2-methyl aziridine at present, but synthetic efficiency is low, and the side effect of synthetic process There are many products, which are harmful to the environment

Method used

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  • Preparation method of 2-methylaziridine
  • Preparation method of 2-methylaziridine
  • Preparation method of 2-methylaziridine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Raw materials

[0026]

[0027]

[0028] Second, the reaction principle

[0029] The present invention is raw material synthesis 2-methyl aziridine by isopropanolamine, sulfuric acid and liquid caustic soda, synthetic principle is as follows figure 1 shown.

[0030] Third, the synthesis process

[0031] (1) Esterification and hydrolysis

[0032] Use a pump to add 100kg of isopropanolamine, 133kg of sulfuric acid and 385kg of liquid caustic soda into the first metering tank, the second metering tank and the third metering tank respectively, and pass through the first metering tank, the second metering tank and the third metering tank of the cooling system Control the temperature at 4°C.

[0033] The isopropanolamine in the first metering tank is all transferred in the esterification hydrolysis reactor, the stirrer is opened, and the sulfuric acid in the second metering tank is added dropwise in the esterification hydrolysis reactor (open circulating water co...

Embodiment 2

[0039] 1. Raw materials

[0040] raw material name Specification% factory Quantity kg Isopropanolamine ≥99％ Shanghai Boying Chemical 100 sulfuric acid ≥98％ Shanghai Nanwei Chemical 120 Liquid caustic soda ≥32％ Tianjin Zhonglian Huasheng Chemical Co., Ltd. 350 solid sodium hydroxide ≥96％ Tianjin Zhonglian Huasheng Chemical Co., Ltd. 30

[0041] 2. Reaction principle

[0042] The present invention is raw material synthesis 2-methyl aziridine by isopropanolamine, sulfuric acid and liquid caustic soda, synthetic principle is as follows figure 1 shown.

[0043] 2. Synthesis process

[0044] 3. (1) Esterification and hydrolysis

[0045] Use a pump to add 100kg of isopropanolamine, 120kg of sulfuric acid and 350kg of liquid caustic soda into the first metering tank, the second metering tank and the third metering tank respectively, and pass through the first metering tank, the second metering tank and the third metering tank ...

Embodiment 3

[0051] 1. Raw materials

[0052]

[0053]

[0054] 2. Reaction principle

[0055] The present invention is raw material synthesis 2-methyl aziridine by isopropanolamine, sulfuric acid and liquid caustic soda, synthetic principle is as follows figure 1 shown.

[0056] 4. Synthesis process

[0057] (1) Esterification and hydrolysis

[0058] Use a pump to add 100kg of isopropanolamine, 250kg of sulfuric acid and 480kg of liquid caustic soda into the first metering tank, the second metering tank and the third metering tank respectively, and pass through the first metering tank, the second metering tank and the third metering tank of the cooling system Control the temperature at 0°C.

[0059] The isopropanolamine in the first metering tank is all transferred in the esterification hydrolysis reactor, the stirrer is opened, and the sulfuric acid in the second metering tank is added dropwise in the esterification hydrolysis reactor (open circulating water cooling in due cour...

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Abstract

The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of 2-methylaziridine. The 2-methylaziridine is synthesized from isopropanolamine, sulfuric acid and liquid caustic soda as raw materials, the synthesis condition is mild, and mass industrial production is facilitated. Besides, the synthesis materials are simple, sulfate esterification and liquid caustic soda hydrolysis are adopted, caustic soda flakes are used for purification in the distillation and purification process, few byproducts are produced, and the method is green and environmentally friendly; initial distillation under normal pressure and fine distillation under low pressure are adopted, and the obtained 2-methylaziridine has the purity of 99% or above.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a preparation method of 2-methylaziridine. Background technique [0002] 2-Methylaziridine, also known as propylene imine, is often used as an adhesive, curing agent and solid rocket fuel. The list of carcinogens released by the International Agency for Research on Cancer of the World Health Organization is a preliminary collation reference, and 2-methylaziridine is included in the list of 2B carcinogens. [0003] 2-methyl aziridine is a kind of important pharmaceutical intermediate, has extensive application in many fields, there are many kinds of synthetic techniques of 2-methyl aziridine at present, but synthetic efficiency is low, and the side effect of synthetic process There are many products, which are harmful to the environment. Contents of the invention [0004] Aiming at the shortcomings of the above-mentioned prior art, the present invention provides a...

Claims

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Application Information

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IPC IPC(8): C07D203/08
CPCC07D203/08
Inventor 沈健吴天平谢韦邱欣欣祁刚
Owner NINGXIA JOIE MATERIAL CO LTD