Chlorin derivative useful in photodynamic therapy and diagnosis
A technology for chlorin and medicine, applied in the field of sodium chlorin e4 and its preparation, and can solve problems such as toxic skin sensitization and the like
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0135] Successfully treated a 70-year-old female patient with invasive extended breast cancer and lymph node metastases in the right axilla. Before treatment, a large cancer mass was observed in the right breast and a small cancer mass was observed in the right armpit. Treatment consists of three courses. For each course, five doses of 62.5-187.5 mg chlorin e4 sodium were administered orally over an eight-day course. 24-48 hours after each oral administration of sodium chlorin e4, the patient was treated with laser and LED light having wavelengths of 660 nm and 760 nm.
[0136] After treatment, Doppler ultrasound analysis revealed that the large cancerous mass in the breast showed little vascularity, no blood vessels leading to it. The cancer mass did not decrease in size, however, the outline of the mass was solid and smooth, showing an inactive, nongrowing tumor. The smaller lymph node carcinoma mass also showed little vascularity and decreased in size from 1.9 cm to 1 cm...
Embodiment 2
[0140] A 62 year old male patient with nasopharyngeal carcinoma with lymph nodes extending into the left neck was successfully treated. The treatment consists of three courses. For each course of treatment, five doses of 62.5-187.5 mg of chlorin e4 sodium were administered orally in a course of eight days. 24-48 hours after each oral administration of sodium chlorin e4, the patient was treated with laser and LED light having a wavelength of 660 nm and 760 nm.
[0141] Immediately after treatment, a lymph node biopsy of the treated neck showed benign or noncancerous lymph nodes with no cancer cells detected. This was confirmed by another biopsy ten months after treatment. CT scans obtained one month before treatment and ten months after treatment showed that the tumor had not spread and had decreased in size.
[0142] Subsequently, the patient is treated with another course of treatment. Again, for this course, five doses of 62.5-187.5 mg chlorin e4 sodium were administered...
Embodiment 3
[0145] A 71 year old male patient with advanced metastatic renal disease with metastases in the gallbladder, liver and lungs was successfully treated. The treatment consists of three courses. For each course of treatment, five doses of 62.5-187.5 mg of chlorin e4 sodium were administered orally in a course of eight days. 24-48 hours after each oral administration of sodium chlorin e4, the patient was treated with laser and LED light having a wavelength of 660 nm and 760 nm.
[0146] PCT / CT scans immediately before treatment and at two, three, five and 15 months after treatment showed complete disappearance of some tumors and reduction in size of the remaining tumors throughout the patient. No further metastasis was observed.
[0147] Subsequently, patients were treated with two additional courses of treatment. Again, for each course, five doses of 62.5-187.5 mg chlorin e4 sodium were administered orally over an eight-day course. 24-48 hours after each oral administration o...
PUM
| Property | Measurement | Unit |
|---|---|---|
| diameter | aaaaa | aaaaa |
| absorbance | aaaaa | aaaaa |
| absorbance | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More