A Weak Coherence Tomography System and Method Based on Fizeau Interference Principle
A tomographic imaging and weak coherence technology, which is applied in the fields of biomedical imaging and optical detection, can solve the problems of not being applicable to common application scenarios and high vibration requirements, and achieve the effect of isolating the impact of vibration and reducing environmental constraints
Active Publication Date: 2022-01-28
CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACADEMY OF SCI +1
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[0016] In view of this, the object of the present invention is to provide a weak coherence tomography system and method based on the principle of Fizeau interference that can enter turbid medium tomography, to overcome the high vibration requirements of the existing parallel coherence tomography system, which does not Deficiencies in common application scenarios
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[0048] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the drawings provided in the following embodiments are only used to illustrate the basic idea of the present invention in a schematic manner, and the following embodiments and features in the embodiments can be combined with each other without conflict.
[0049] Among them, the accompanying drawings are only used for exemplary description, and represent only schematic diagrams, not physical drawings, and should ...
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The invention relates to a weak coherence tomography system and method based on the principle of Fizeau interference, belonging to the technical field of biomedical imaging and optical detection. The system includes an illumination arm, a sample arm, a detection arm and an information processing unit; the illumination arm is used to collimate the weakly coherent light to irradiate the sample; the sample arm is used to relay the illumination beam to the surface and inside of the sample, and its front end contains a protective window, The reference beam returned by the protection window will interfere with the sampling beam returned by the image plane on the detector surface; the detection arm receives and processes the weak phase interference signal, extracts the sample information, and forms an interference pattern on the detector surface; the information processing unit combines the reference beam and The interference pattern formed by the sampling beam is analyzed to obtain the optical property information of the sample. The invention can isolate the influence of vibration, reduce environmental constraints, overcome the problem of failure of the existing coherent tomography system due to micron-level vibration, and realize non-destructive penetrating turbid medium imaging and detection in common application scenarios.
Description
technical field [0001] The invention belongs to the technical field of biomedical imaging and optical detection, and relates to a weak coherence tomography system and method based on the principle of Fizeau interference. Background technique [0002] In biological and pathological research, living tissue cell detection is the most reliable method for judging pathogen drug response and early lesions. At present, cell detection adopts paraffin or freezing method. The tissue is frozen (40 minutes) or paraffin-fixed (24 hours) and made into sections with a thickness of about several microns. Its disadvantages are: the original environment is damaged, and it cannot reflect the original appearance of lesions and cells; due to the inaccurate position of the slices, the interpretation depends on the prior knowledge of cell morphology characteristics, etc., which is highly subjective and leads to misdiagnosis. [0003] In order to perform rapid cell detection without processing, ima...
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IPC IPC(8): G01N21/45
CPCG01N21/45
Inventor 王金玉汪岳峰尹韶云杜凯李刚熊亮
Owner CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACADEMY OF SCI