A kind of preparation method and application of schiff base complex containing rare earth element europium
A technology of rare earth elements and complexes, applied in the field of medicine, can solve the problems of complex process and long preparation period
Active Publication Date: 2021-09-10
SHAANXI SCI TECH UNIV
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Problems solved by technology
The process of synthesizing such complexes may be complicated and the preparation period is long
Method used
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Embodiment 1
[0028] Mix methanol and acetonitrile at a volume ratio of 2:1 to obtain mixed solvent 1;
[0029] Mixed solvent 2 was obtained by mixing acetonitrile and dichloromethane at a volume ratio of 1:1.
[0030] Mixed solvent 3 was obtained by mixing methanol and water at a volume ratio of 1:1.
Embodiment 2
[0032] 1 mmol of 5-methoxy salicylaldehyde and 1 mmol of 1,3-propylenediamine were dissolved in 4 mL of mixed solvent 1, and aldol condensation reaction was carried out at room temperature to obtain Schiff base ligand compound 1.
Embodiment 3
[0034] 1 mmol of 5-methoxy salicylaldehyde and 1 mmol of 1,3-propylenediamine were dissolved in 5 mL of mixed solvent 2, and aldol condensation reaction was carried out at room temperature to obtain Schiff base ligand compound 2.
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The invention belongs to the technical field of medicine, in particular to a preparation method and application of a Schiff base complex containing rare earth element europium. The molecular formula of the complex is: C 19 h 25 CuN 5 EuO 16 . The present invention obtains solution 1 by dissolving copper salt and rare earth metal europium in a mixed solvent under constant stirring; then dissolving the Schiff base ligand compound in the mixed solvent, adding solution 1 to solution 2, and stirring constantly After 0.5-1.0 h, the solution 3 was obtained after filtration; the solution 3 was then placed in a high-pressure reactor, and after the temperature was raised and lowered under program control, a rare earth Schiff base complex with light blue massive crystals was obtained. The rare earth Schiff base complex of the invention has good crystal form stability, and the preparation method and post-treatment method are relatively simple. In the superoxide dismutase activity (inhibition rate) test, the activity of its Schiff base complex was significantly enhanced compared with that before coordination, which provided a preparation method for the future design and synthesis of rare earth Schiff base complexes and simulated superoxide dismutase. Biological activity provides a realistic basis.
Description
technical field [0001] The invention belongs to the technical field of medicine, in particular to a preparation method and application of a Schiff base complex containing rare earth element europium. Background technique [0002] Superoxide dismutase (SOD) widely exists in organisms and is an important metalloenzyme for the body to scavenge superoxide anion free radicals. It plays an important role in the body's antioxidant balance. Therefore, it needs to be supplemented in time. Studies have shown that SOD has biological and pharmacological effects such as anti-aging, anti-inflammation, and anti-cancer, and can also be used for the treatment of many diseases related to active oxygen damage. At present, researchers have synthesized and characterized a series of small-molecule complexes containing metal ions such as copper, manganese, and iron to simulate SOD. It is expected that small-molecule mimic compounds can be used instead of SOD for clinical application in the future....
Claims
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IPC IPC(8): C07F19/00A61P39/06
CPCA61P39/06C07B2200/13C07F5/003
Inventor 葛红光唐小波史娟庞海霞卢久富
Owner SHAANXI SCI TECH UNIV