Method and system for detection and localization of specific region boundary for samples with complex components

Abstract

The invention relates to a specific area boundary detection and positioning method and system for samples with complex components, which specifically includes: shaping the outgoing laser, and the cylindrical laser shaped by the cylindrical lens is vertically irradiated on the horizontal plane of the sample; Change the position where the columnar laser is irradiated on the horizontal plane of the sample to be tested, collect the photoacoustic signal, and through signal processing, the combined spectrum-acoustic power spectrum at the position of the sample to be tested can be obtained, and the joint difference spectrum-acoustic power spectrum can be obtained The amplitude of the sound power spectrum after normalizing the upper energy can determine the molecular chemistry, microstructure and other information at the position of the sample to be inspected, and then perform boundary detection and positioning. The system includes a pulsed laser source, a glass slide, a needle hydrophone, an amplifier, Oscilloscope, cylindrical lens, galvomirror and computer; the present invention aims at the problem that current medical equipment can only perform boundary detection, location and distinction from a physical point of view, and proposes a new boundary detection scheme, which has the dual advantages of high sensitivity and deep penetration depth.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to a method and system for boundary detection and positioning of a specific area for complex component samples. Background technique [0002] One of the main reasons for the postoperative survival rate is that not all the tissue in a specific area was removed during the operation, resulting in residual positive margins. [0003] With the development of the times, how to achieve accurate and rapid identification of boundaries in specific regions during surgery has become a common goal in the medical field. At present, the existing new technologies for intraoperative auxiliary calibration of boundaries include: intraoperative ultrasound assistance, intraoperative CT, intraoperative In MRI, etc., the above technologies have their own advantages and disadvantages. They are unable to distinguish tissues with similar physical properties but different chemical properties. A metho...

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Problems solved by technology

[0004] The purpose of the present invention is to provide a specific area boundary detection and positioning method and system for complex component samples in order to overcome the above-mentioned defects in the prior art, aiming at the existing boundary detection and positioning technology can only be determined from a physical point Due to the limitation of the boundary detection and positioning of the specific area of ​​the sample, a method is proposed to analyze the tissue components from the chemical molecular level to determine the properties of the tissue, and compare the differences between different positions in the specific area of ​​​​the horizontal plane of the sample to be tested and the reference tissue through differential calculation. The difference spectrum-acoustic power spectrum joint map can distinguish the molecular chemistry, microstructure and other information of adjacent tissue regions, so as to achieve the purpose of boundary calibration

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