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A kind of isolated windproof polysaccharide and its application

A polysaccharide and glucose technology, applied in the field of medicine, can solve problems such as diabetes and hyperlipidemia that have not been reported yet

Active Publication Date: 2022-01-18
SHANGHAI GREEN VALLEY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on the use of polysaccharides from windbreaks for the treatment of diabetes or hyperlipidemia

Method used

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  • A kind of isolated windproof polysaccharide and its application
  • A kind of isolated windproof polysaccharide and its application
  • A kind of isolated windproof polysaccharide and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Embodiment 1: the preparation of windproof polysaccharide

[0082] (1) Add 9 L of 0.1 mol / L NaOH aqueous solution to 300 g of Fangfeng decoction pieces. The Radix Fangfeng decoction pieces were extracted with the NaOH aqueous solution at 90° C. for 3 hours to obtain an alkaline extract. After separating the alkaline extract, repeat the extraction twice, each time using 9L 0.1mol / L NaOH aqueous solution, each time for 3 hours. Combine the resulting alkaline extracts.

[0083] (2) adding hydrochloric acid to the alkaline extract to adjust the pH to 7 to obtain a neutral extract, and concentrating the neutral extract to 2L.

[0084] (3) adding ethanol to the neutral extract to obtain a mixture with an ethanol concentration of 20%, and centrifuging the mixture to obtain a supernatant.

[0085] (4) adding ethanol to the supernatant to obtain a mixture with an ethanol concentration of 80%, and centrifuging the mixture to obtain a precipitate;

[0086] (4') Add 0.5 L of di...

Embodiment 2

[0088] Embodiment 2: the preparation of windproof polysaccharide

[0089] (1) Add 9L of 0.05mol / L KOH aqueous solution to 300g Fangfeng decoction pieces. Extract the Radix decoction pieces with the KOH aqueous solution at 40° C. for 4 hours to obtain an alkaline extract. After separating the alkaline extract, the extraction was repeated 3 times, using 9 L of 0.05 mol / L KOH aqueous solution for 4 hours each time. Combine the resulting alkaline extracts.

[0090] (2) Add formic acid to the alkaline extract to adjust the pH to 7 to obtain a neutral extract, which is concentrated to 2L.

[0091] (3) Methanol was added to the neutral extract to obtain a mixture with a methanol concentration of 30%, and the mixture was centrifuged to obtain a supernatant.

[0092] (4) adding methanol to the supernatant to obtain a mixture with a methanol concentration of 90%, and centrifuging the mixture to obtain a precipitate;

[0093] (4') Add 0.5 L of distilled water to the precipitate to di...

Embodiment 3

[0095] Embodiment 3: the preparation of windproof polysaccharide

[0096] (1) Add 5mol / L of Na to 300g Fangfeng decoction pieces 2 CO 3 Aqueous solution 3L. at 90°C with the Na 2 CO 3 Extract the Fangfeng decoction pieces with an aqueous solution for 1 hour to obtain an alkaline extract. After separating the alkaline extract, repeat the extraction 3 times, each using 3L5mol / L of Na 2 CO 3 Aqueous solution, 1 hour each time. Combine the resulting alkaline extracts.

[0097] (2) Add acetic acid to the alkaline extract to adjust the pH to 7 to obtain a neutral extract, and concentrate the neutral extract to 2L.

[0098](3) Add ethanol to the neutral extract to obtain a mixture with an ethanol concentration of 15%, and centrifuge the mixture to obtain a supernatant.

[0099] (4) adding ethanol to the supernatant to obtain a mixture with an ethanol concentration of 80%, and centrifuging the mixture to obtain a precipitate;

[0100] (4') Add 0.5 L of distilled water to the...

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Abstract

This application relates to the field of medicine. The present application relates to an isolated windproof polysaccharide and its use in the preparation of medicines for treating diabetes or hyperlipidemia. In particular, the present application relates to an isolated parsnip polysaccharide comprising L-arabinose, D-galacturonic acid, D-mannose, D-glucose and D-galactose, wherein L-arabinose, D-galactose The molar ratio of aldehyde acid, D-mannose, D-glucose and D-galactose is 1-20:1-10:1-10:1-15:1-10, preferably 10-15:1-5: 1‑5: 5‑10: 5‑10.

Description

technical field [0001] This application relates to the field of medicine. Specifically, the present application relates to an isolated Saposhnikovia Divaricata polysaccharide (SDP) and its use in the preparation of medicines for treating diabetes or hyperlipidemia. Background technique [0002] Recent studies have found that carbohydrates are not only an important class of structural and energy substances, but also have important biological functions. Carbohydrates participate in the mutual recognition and information transmission process between cells, and are considered to be another important information molecule in organisms besides nucleic acid. Moreover, carbohydrates are also key factors in cell surface signal recognition, antigen-antibody response, intercellular information transmission and perception. Therefore, the research on polysaccharides with biological activity has been paid more and more attention. Due to the complex structure of carbohydrates, their sepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P3/10A61P3/06
CPCC08B37/006C08B37/0003A61K31/715
Inventor 张真庆徐乃玉殷翔沈路路庞力薛洁
Owner SHANGHAI GREEN VALLEY PHARMA