A Method for Identifying Raman Spectrum Abnormal Measurement Signals
A technology for measuring signals and Raman spectroscopy, applied in Raman scattering, material excitation analysis, etc., can solve the problems of misjudgment of drug categories, increase the difficulty of identification of abnormal signal types, etc., and achieve the effect of ensuring effectiveness
Active Publication Date: 2021-11-19
NANJING FORESTRY UNIV
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Problems solved by technology
In the rapid inspection of drugs using Raman spectroscopy, the use of abnormal signals for analysis will cause misjudgment of drug categories
At present, the identification of abnormal spectra in most studies is based on the modeling sample set combined with pattern recognition methods such as Mahalanobis distance and leverage value. In the abnormal signal based on pattern recognition detection, there may be anomalies caused by the signal itself being invalid or confusion caused by the effective signal being a new type of anomaly, which increases the difficulty of identifying the type of abnormal signal, resulting in food or drug testing results. Therefore, as a preventive mechanism, Before using the sample spectrum for formal analysis, the abnormal signal in the single and repeated measurement of the sample is automatically identified, and the interference caused by the abnormal signal itself to the subsequent pattern recognition judgment is eliminated, so as to provide accurate and reliable qualitative and quantitative analysis for subsequent substances. source of information
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[0021] specific implementation plan
[0022] The present invention will be further described more clearly and completely below, obviously, the described examples are only some examples of the present invention, rather than all the embodiments.
[0023] A method for identifying abnormal Raman spectrum measurement signals provided by the present invention comprises the following steps:
[0024] In step 1, the spectral data of the sample is collected, and the spectral data are sampled at equal intervals according to the spectral length to form an initial spectral sequence.
[0025] Spectral data of the samples collected above are specifically:
[0026] The spectrum recognition method combining the amplitude method and the first order differential is used to detect the peak and valley points; after the peak and valley points are identified, the tape method is used to determine the baseline, and then the baseline is subtracted to obtain a signal-to-noise ratio that eliminates base...
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The invention provides a method for identifying abnormal Raman spectrum measurement signals, which can identify and eliminate abnormal spectra in single Raman spectrum measurement and parallel measurement. After eliminating the baseline drift for the single measurement spectral signal, estimate the signal-to-noise ratio; subtract the baseline for the parallel measurement spectral signal, calculate the standard deviation of each wave point of each measurement spectrum relative to the average spectrum, and add them to calculate the total average standard deviation. Design a suitable threshold to eliminate abnormal signals in single measurement and parallel measurement to ensure the accuracy and adaptability of subsequent qualitative and quantitative analysis of Raman spectroscopy.
Description
technical field [0001] The invention belongs to the technical field of Raman spectrum analysis, and in particular relates to a method for identifying abnormal measurement signals in the process of collecting Raman spectra. Background technique [0002] Raman spectroscopy has the advantages of no need for sample pretreatment, short operation time, simplicity, and high sensitivity, and can accurately perform qualitative and quantitative analysis of substances. It has been widely used in petrochemical, biomedical, geological archaeology, criminal justice and other fields. . Raman spectrum peaks are usually sharper, making it easier to identify mixtures. However, in Raman spectroscopy tests, fluorescence interference is often encountered, and because the Raman scattered light itself is extremely weak, the background will drown out the Raman signal. At the same time, Raman spectroscopy is an absolute intensity measurement without background, which is easily interfered by externa...
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IPC IPC(8): G01N21/65
CPCG01N21/65
Inventor 熊智新张肖雪刘耀瑶
Owner NANJING FORESTRY UNIV