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A kind of microcrystalline cellulose with high bulk density and its production process

A technology of microcrystalline cellulose and bulk density, which is applied in the field of high bulk density microcrystalline cellulose and its production technology, can solve the problems such as difficulty in meeting the needs of microcrystalline cellulose, and achieves a technology with increased disintegration performance and good fluidity. Effect

Active Publication Date: 2021-08-10
珠海市东辰制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] With the development of science and technology, people have found that the bulk density of microcrystalline cellulose is mainly directly related to the molecular weight of the obtained microcrystalline cellulose, and secondly related to the particle size of microcrystalline cellulose. Although using the above two Conditions, the bulk density of microcrystalline cellulose produced by the existing technology can generally reach 0.3-0.5g / cm 3 , but it is difficult to meet the further demand for high bulk density microcrystalline cellulose in the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A high bulk density microcrystalline cellulose and its production process, comprising the following steps:

[0029] (1) Hydrolysis: using 0.4mol / L dilute hydrochloric acid, under the condition of reaction temperature of 110 degrees Celsius, the microcrystalline cellulose dissolving pulp is hydrolyzed to a limit polymerization degree of 150;

[0030] (2) Filtration: filter the microcrystalline cellulose dissolving pulp with a limit polymerization degree of 150, wash the filter cake with drinking water until the filtrate is neutral, then wash with purified water until the conductivity of the filtrate is 72 μs / cm, filter Cake spare;

[0031] (3) Kneading: the filter cake is placed in a kneader and kneaded; the forward-rotating paddle and the reverse-rotating paddle in the kneader are selected in a Z shape, and the rotating speed of the forward-rotating paddle is set to 37 rpm, and the rotating speed of the reverse-rotating paddle is 22 rpm. minutes, kneading for 20 minute...

Embodiment 2

[0042] A high bulk density microcrystalline cellulose and its production process, comprising the following steps:

[0043] (1) Hydrolysis: using 0.5mol / L dilute hydrochloric acid, under the condition of reaction temperature of 100 degrees Celsius, the microcrystalline cellulose dissolving pulp is hydrolyzed to a limit polymerization degree of 166;

[0044] (2) Filtration: filter the microcrystalline cellulose dissolving pulp with a limit polymerization degree of 166, wash the filter cake with drinking water until the filtrate is neutral, then wash with purified water until the conductivity of the filtrate is 75 μs / cm, filter Cake spare;

[0045] (3) Kneading: the filter cake is placed in a kneader and kneaded; the forward and reverse paddles in the kneader are in a Z shape, and the rotating speed of the forward rotating paddle is set to 42 rpm, and the rotating speed of the reverse paddle is 36 rpm. minutes, kneading for 25 minutes.

[0046] (4) beating: take out the kneaded...

Embodiment 3

[0056] A high bulk density microcrystalline cellulose and its production process, comprising the following steps:

[0057] (1) Hydrolysis: using 0.6mol / L dilute hydrochloric acid, under the condition of reaction temperature of 95 degrees Celsius, the microcrystalline cellulose dissolving slurry is hydrolyzed to a limit polymerization degree of 180;

[0058] (2) Filtration: filter the microcrystalline cellulose dissolving pulp with a limit polymerization degree of 180, wash the filter cake with drinking water until the filtrate is neutral, then wash with purified water until the conductivity of the filtrate is 70 μs / cm, filter Cake spare;

[0059] (3) Kneading: the filter cake is placed in a kneader and kneaded; the forward and reverse paddles in the kneader are in a W shape, and the rotating speed of the forward rotating paddle is set to 50 rpm, and the rotating speed of the reverse paddle is 38 rpm. minutes, kneading for 30 minutes.

[0060] (4) beating: take out the kneade...

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PUM

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Abstract

The invention relates to the field of microcrystalline cellulose, in particular to a high bulk density microcrystalline cellulose and a production process thereof. On the premise of the same molecular weight and the same particle size of the microcrystalline cellulose, a physical method is adopted to increase the bulk density, The produced microcrystalline cellulose has a particle size D10 of 10-30 μm, D50 of 45-70 μm, D90 of 110-180 μm, and a bulk density of 0.60-0.65 g / cm 3 , which greatly meets the differentiated needs of the market.

Description

technical field [0001] The invention relates to the field of microcrystalline cellulose, in particular to a high bulk density microcrystalline cellulose and a production process thereof. Background technique [0002] Microcrystalline cellulose is often used in the fields of medicine, food and cosmetics. In the pharmaceutical industry, microcrystalline cellulose is often used as a disintegrant for preparations—when the preparation encounters liquid, water quickly enters the preparation containing microcrystalline cellulose , the hydrogen bond of microcrystalline cellulose breaks immediately, so that the preparation disintegrates and releases, so when the bulk density of microcrystalline cellulose is larger, its fluidity is better and its disintegration is faster. [0003] With the development of science and technology, people have found that the bulk density of microcrystalline cellulose is mainly directly related to the molecular weight of the obtained microcrystalline cellu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B15/02
CPCC08B15/02
Inventor 段民英杨登科李洪文
Owner 珠海市东辰制药有限公司