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Application of STEAP1 in diagnosis, treatment and prognosis of ovarian cancer

A technology for ovarian cancer and ovarian cancer cells, applied in the fields of biomedicine and molecular biology, can solve problems such as unclear clinical significance and effects, and achieve the effects of promoting invasion and metastasis, inhibiting apoptosis, and promoting proliferation

Active Publication Date: 2019-09-13
SHANDONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

STEAP1 was cloned for the first time in advanced prostate cancer, it is highly expressed in human prostate cancer, and its expression is upregulated in various cancers. However, the inventors found that its clinical significance and role in cancer cells are still unclear, especially its Little research has been done on its role in ovarian cancer

Method used

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  • Application of STEAP1 in diagnosis, treatment and prognosis of ovarian cancer
  • Application of STEAP1 in diagnosis, treatment and prognosis of ovarian cancer
  • Application of STEAP1 in diagnosis, treatment and prognosis of ovarian cancer

Examples

Experimental program
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Effect test

Embodiment 1

[0056] 1 Materials and methods

[0057] 1.1 Materials

[0058] 1.1.1 Source of tissue samples

[0059] From January 2007 to December 2016, a total of 594 human ovarian tissue specimens were collected from Qilu Hospital and Provincial Hospital in Shandong Province, including 65 normal ovarian tissues, 145 benign ovarian tumors and 384 epithelial ovarian cancer tissues. Specimens (142 cases of serous cystadenocarcinoma, 137 cases of mucinous cystadenocarcinoma, 105 cases of endometrioid carcinoma). All ovarian cancer patients were clinically staged according to the FIGO staging system, including 73 cases of FIGO stage I, 105 cases of FIGO stage II, and 206 cases of FIGO stage III and IV. None of the patients received preoperative radiotherapy or chemotherapy. This study was approved by the Medical Ethics Committee of Shandong University and was performed with the informed consent of the patients.

[0060] 1.1.2 Source of cells

[0061] Ovarian cancer cell lines ES-2, SKOV-3...

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Abstract

The present invention provides application of STEAP1 in diagnosis, treatment and prognosis of ovarian cancer. The research shows that STEAP1 plays an oncogene role in the ovarian cancer, and the highexpression of the STEAP1 is positively related to the malignant phenotype of the ovarian cancer and the poor prognosis of a patient; the STEAP1 can promote the proliferation of ovarian cancer cells and inhibit the apoptosis of the cells. The STEAP1 can promote invasion and metastasis of ovarian cancer cells by promoting the progression of EMT. The invention shows that the STEAP1 is an oncogene participating in the generation and development of the ovarian cancer, can be used as a biological marker and a treatment target of the the ovarian cancer, and has good practical application value.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and molecular biology, and specifically relates to the application of STEAP1 in the diagnosis, treatment and prognosis of ovarian cancer. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Ovarian cancer is one of the common malignant tumors of female reproductive organs, and its incidence rate ranks third after cervical cancer and uterine body cancer. However, the mortality rate of ovarian cancer ranks first among all kinds of gynecological tumors, posing a serious threat to women's lives. Due to the complex embryonic development, tissue anatomy and endocrine function of the ovary, the earl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886A61K45/00A61P15/00
CPCA61K45/00A61P15/00C12Q1/6886C12Q2600/118C12Q2600/158
Inventor 陈洁张捷刘晓燕王来城尹秀秀王甜甜解洁孙佳丽
Owner SHANDONG UNIV
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