Application of STEAP1 in diagnosis, treatment and prognosis of ovarian cancer

A technology for ovarian cancer and ovarian cancer cells, applied in the fields of biomedicine and molecular biology, can solve problems such as unclear clinical significance and effects, and achieve the effects of promoting invasion and metastasis, inhibiting apoptosis, and promoting proliferation
CN110229896AActive Publication Date: 2019-09-13SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2019-09-13

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Abstract

The present invention provides application of STEAP1 in diagnosis, treatment and prognosis of ovarian cancer. The research shows that STEAP1 plays an oncogene role in the ovarian cancer, and the highexpression of the STEAP1 is positively related to the malignant phenotype of the ovarian cancer and the poor prognosis of a patient; the STEAP1 can promote the proliferation of ovarian cancer cells and inhibit the apoptosis of the cells. The STEAP1 can promote invasion and metastasis of ovarian cancer cells by promoting the progression of EMT. The invention shows that the STEAP1 is an oncogene participating in the generation and development of the ovarian cancer, can be used as a biological marker and a treatment target of the the ovarian cancer, and has good practical application value.
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Description

technical field

[0001] The invention belongs to the technical fields of biomedicine and molecular biology, and specifically relates to the application of STEAP1 in the diagnosis, treatment and prognosis of ovarian cancer. Background technique

[0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art.

[0003] Ovarian cancer is one of the common malignant tumors of female reproductive organs, and its incidence rate ranks third after cervical cancer and uterine body cancer. However, the mortality rate of ovarian cancer ranks first among all kinds of gynecological tumors, posing a serious threat to women's lives. Due to the complex embryonic development, tissue anatomy and endocrine function of the ovary, the earl...

Claims

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