Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New antimicrobial composition and preparation method and application thereof

A technology of anti-microbial and anti-microbial agents, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, anti-viral agents, etc., can solve the problems of unstudied anti-viral effects of LAE alone, untaught, etc., and achieve obvious anti-blistering properties Effect of stomatitis virus activity

Pending Publication Date: 2019-10-08
EAST CHINA NORMAL UNIV
View PDF7 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method involves a variety of cationic compound disinfectant components including LAE, and the antiviral effect of LAE alone was not studied
At the same time, this invention only teaches the use of the composition for object surface disinfection and space disinfection or sterilization, and does not teach how to use a single LAE component for antiviral agents

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New antimicrobial composition and preparation method and application thereof
  • New antimicrobial composition and preparation method and application thereof
  • New antimicrobial composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Example 1: The preparation method of the ion-pair compound synthesized by lauroyl arginine ethyl ester hydrochloride and nicotinic acid

[0071] Dissolve 2.0 g of sodium nicotinate (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) in 50 mL of water to prepare sodium nicotinic acid salt solution (A); dilute 6.8 g of ethyl lauroyl arginate hydrochloride Dissolve in 40mL of water, heat to 90°C until ethyl lauroyl arginine hydrochloride is completely dissolved to make ethyl lauroyl arginine hydrochloride aqueous solution (B); Slowly add the saline solution (A) into the aqueous solution of lauroyl arginine ethyl ester hydrochloride (B), stir continuously, react for 2 hours, cool to room temperature, filter, wash the precipitate fully with pure water, and dry the precipitate under vacuum at 60°C. That is, 7.6 g of the nicotinic acid ion pair compound was obtained. Embodiment two lauroyl arginine ethyl ester nicotinic acid ion pair compound molecular for...

Embodiment 2

[0071] Dissolve 2.0 g of sodium nicotinate (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) in 50 mL of water to prepare sodium nicotinic acid salt solution (A); dilute 6.8 g of ethyl lauroyl arginate hydrochloride Dissolve in 40mL of water, heat to 90°C until ethyl lauroyl arginine hydrochloride is completely dissolved to make ethyl lauroyl arginine hydrochloride aqueous solution (B); Slowly add the saline solution (A) into the aqueous solution of lauroyl arginine ethyl ester hydrochloride (B), stir continuously, react for 2 hours, cool to room temperature, filter, wash the precipitate fully with pure water, and dry the precipitate under vacuum at 60°C. That is, 7.6 g of the nicotinic acid ion pair compound was obtained. Embodiment two lauroyl arginine ethyl ester nicotinic acid ion pair compound molecular formula, the analysis of molecular weight

[0072] by mass spectrometry, 1 H-NMR, 13 The molecular formula of the compound obtained by C-NMR spect...

Embodiment 3

[0078] Example 3: Preparation method of ethyl lauroyl arginine hydrochloride and tartaric acid synthetic ion pair compound

[0079] Dissolve 2.0 g of tartaric acid (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) in 50 mL of methanol, add an equivalent amount of NaOH, stir at room temperature until a white solid precipitates, filter with suction and wash three times with 30 mL of methanol to obtain sodium tartrate . Sodium tartrate salt was dissolved in 50mL of water to make sodium tartrate aqueous solution (A); Dissolve 5.6g of ethyl lauroyl arginine hydrochloride in 40mL of water and heat to 90°C until ethyl lauroyl arginine salt The acid salt was completely dissolved to make ethyl lauroyl arginine hydrochloride aqueous solution (B); at 90°C, sodium tartrate aqueous solution (A) was slowly added to ethyl lauroyl arginine hydrochloride aqueous solution ( In B), stir continuously, react for 2 hours, cool to room temperature, filter, wash the precipitate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides an antimicrobial composition, which comprises a lauroyl lauroyl arginate (LAE) ion pair derivative, and the antimicrobial composition is an antiviral agent against an enveloped virus, wherein the enveloped virus is selected from vesicular stomatitis virus of the herpes virus, or the Newcastle disease virus selected from the paramyxovirus. The antiviral agent is the anti-infective agent comprising a condensate derived from fatty acid and esterified binary amino acid, and is capable of acting on Newcastle disease virus and vesicular stomatitis virus in-vitro, and reducing the infection of Newcastle disease virus and vesicular stomatitis virus to cells. The antiviral agent is added to the cultured Newcastle disease virus (NDV) and vesicular stomatitis virus (VSV), or the antiviral agent is added at different times before the virus is infected and after the infection, the infected cells are detected, and the number of viruses is found to be significantly reduced. The antiviral agent can effectively inhibit or kill the virus and can be used to prevent or reduce the ability of the virus to infect cells. The present invention also provides a method of preparing the antimicrobial composition, which has the characteristics of better virucidal effect and lower dosage than that of the original antimicrobial composition containing a LAE compound.

Description

technical field [0001] The invention relates to the application of the compound lauroyl arginine ethyl ester and its derivatives in the preparation of antiviral agents. Background technique [0002] Newcastle disease is an acute, febrile, septic and highly contagious infectious disease of poultry caused by Newcastle disease virus (NDV), characterized by high fever, dyspnea, diarrhea, nervous disorders, mucosal and serosal hemorrhage, The morbidity and mortality rate can reach more than 90%. It is a major infectious disease that endangers the poultry industry. It is listed as a first-class animal disease by the Ministry of Agriculture of my country. The susceptibility of Newcastle disease is relatively strong, and the possibility of onset occurs in all seasons, among which the incidence rate is higher in autumn, winter and early spring, and all kinds of poultry can be infected, among which geese and ducks have a higher incidence rate; at the same time, sick birds are the sourc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/221A61K31/465A61K31/194A61P31/04A61P31/10A61P31/12A61P31/14A61P31/16A61P31/18A61P31/20A61P31/22
CPCA61K31/194A61K31/221A61K31/465A61P31/04A61P31/10A61P31/12A61P31/14A61P31/16A61P31/18A61P31/20A61P31/22Y02A50/30
Inventor 易正芳高嵩邵婷仇文卫刘明耀
Owner EAST CHINA NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com