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Traditional Chinese medicine compound thermosensitive gel preparation for treating haemorrhoids

A compound temperature-sensitive gel and temperature-sensitive gel matrix technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of temperature-sensitive gel materials that cannot undergo temperature-sensitive phase transition and cannot achieve phase transition effects. To achieve the effect of improving medication compliance, increasing bioavailability, and avoiding drug outflow

Inactive Publication Date: 2019-10-18
成都肛肠专科医院
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The skeleton of temperature-sensitive gel materials is easily affected by metal ions, resulting in failure to achieve the phase transition effect. Alum, one of the main medicinal materials in Lianzhi alum solution, is rich in metal ions, which prevents the temperature-sensitive phase transition of commonly used temperature-sensitive gel materials.

Method used

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  • Traditional Chinese medicine compound thermosensitive gel preparation for treating haemorrhoids
  • Traditional Chinese medicine compound thermosensitive gel preparation for treating haemorrhoids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The prescription of the traditional Chinese medicine extraction fermented liquid of this embodiment: 43.5g of coptis, 31.5g of gardenia, 4.35g of alum.

[0028] The above three flavors, coptis and gardenia are crushed, soaked in water for 24 hours, decocted three times, and alum is added in three equal amounts. Add 8 times the amount of water for the first time, decoct for 45 minutes; add 6 times the amount of water for the second and third times, decoct for 30 minutes, combine the decoction, filter, concentrate the filtrate to 1000ml, and let it stand at room temperature for three weeks. When the liquid surface produces gray-white mold groups, filter and pack the filtrate to obtain the product.

[0029] Prescription of traditional Chinese medicine compound temperature-sensitive gel preparation: 100ml of fermented liquid extracted from traditional Chinese medicine, 11.0g of poloxamer 407, 4.0g of poloxamer 188, and 1.0g of hydroxypropyl methylcellulose.

[0030] Prepar...

Embodiment 2

[0032] The preparation of the traditional Chinese medicine extraction fermentation broth is the same as in Example 1.

[0033] Prescription: 100ml of traditional Chinese medicine extract fermentation broth, 12.0g of poloxamer 407, 2.5g of poloxamer 188, 0.5g of hydroxypropyl methylcellulose, 1.0g of hydroxypropyl β-cyclodextrin.

[0034] Preparation method: take the prescribed amount of hydroxypropyl methylcellulose and hydroxypropyl β-cyclodextrin, dissolve in the prescribed amount of traditional Chinese medicine extraction fermentation broth, add the prescribed amount of poloxamer 407 and poloxamer 188, stir Make the dispersion uniform, and store in the refrigerator at 4°C for more than 24 hours to obtain a brown homogeneous solution.

Embodiment 3

[0036] The preparation of the traditional Chinese medicine extraction fermentation broth is the same as in Example 1.

[0037] Prescription of traditional Chinese medicine compound temperature-sensitive gel preparation: 100ml of fermented broth extracted from traditional Chinese medicine, 5.0g of chitosan, 0.5g of sodium β-glycerophosphate, and 1.0g of hydroxypropyl methylcellulose.

[0038] Preparation method: Dissolve the prescribed amount of chitosan and sodium β-glycerophosphate in the prescribed amount of traditional Chinese medicine extraction fermentation broth in a water bath at 60°C, and obtain a brown homogeneous solution after cooling.

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Abstract

The invention provides a traditional Chinese medicine compound thermosensitive gel preparation for treating haemorrhoids. The traditional Chinese medicine compound thermosensitive gel preparation is prepared from traditional Chinese medicine extract fermentation liquor by adding a proper amount of auxiliary materials, wherein the traditional Chinese medicine materials include, by weight, 87 partsof coptidis rhizoma, 33 parts of fructus gardeniae and 8.7 parts of alum. The traditional Chinese medicine compound thermosensitive gel preparation has the functions of clearing away heat and toxic materials, stopping bleeding and the like, and is mainly used for treating haemorrhoids inflammation, hematochezia, thrombi and other diseases.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and more specifically relates to a compound thermosensitive gel preparation of traditional Chinese medicine with the functions of clearing away heat, detoxifying and stopping bleeding, and is mainly used for treating diseases such as hemorrhoid inflammation, blood in stool and thrombus. Background technique [0002] Hemorrhoids are a common and multiple anal disease, which is a soft vein mass formed by the enlargement and varicose of the rectal veins under the mucous membrane of the end of the rectum and under the skin of the anal canal. Its main features are prolapse, blood in the stool, easy to relapse, and unbearable pain, which seriously affects people's normal work and life. The incidence rate of hemorrhoids is relatively high, according to statistics, 60% of the population suffers from hemorrhoids in various degrees. There is an ancient saying that "nine out of ten peop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/06A61K47/10A61K47/38A61P7/04A61P7/02A61P9/14A61K33/06
CPCA61K9/0031A61K9/06A61K33/06A61K36/718A61K36/744A61K47/10A61K47/38A61K2236/19A61K2236/331A61K2236/39A61P7/02A61P7/04A61P9/14A61K2300/00
Inventor 白俊毅熊婷婷章津铭卿勇杨向东
Owner 成都肛肠专科医院
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