A method for surface modification of degradable stents using laser

A surface modification and laser technology, applied in medical formula, surgery, coating, etc., can solve problems such as unfinished stents and affect the use of stents, achieve structural stability, accelerate the process of endothelialization, and have a wide range of applications

Active Publication Date: 2022-05-13
INNO LASER TECH CORP LTD +1
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Problems solved by technology

However, studies have found that due to the active chemical properties of magnesium, the degradation rate of magnesium alloy stents in the body is too fast, and the mechanical integrity of the stents generally begins to be lost in 5-8 weeks, while the proliferation of vascular endothelial cells and vascular smooth muscle cells is still low. Not enough, the endothelialization process of the stent has not been completed, which affects the use effect of the stent

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  • A method for surface modification of degradable stents using laser

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[0026] In order to make the purpose, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0027] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts fall within the protection scope of the present invention.

[0028] In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Orientation or position indicated by "back", "left", "...

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Abstract

The invention discloses an innovative method for modifying the surface of a degradable stent by using a laser, which includes the following steps: step S1, using a first laser device to process the surface of a stent material according to a preset contour, and forming several micro-depressions on the surface of the material Pit structure; step S2, use the second laser device to process the surface of the stent material according to the preset contour, form a highly cross-linked network structure on the surface of the material, and obtain the material to be treated; step S3, use the adhesion protein inside the material to be treated The surface is wrapped to form an artificial subendothelial matrix layer; wherein, the scaffold material is a magnesium alloy material, which is used to manufacture a degradable scaffold.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a method for modifying the surface of a degradable bracket by using laser. Background technique [0002] With the gradual improvement of medical level, interventional stent reconstruction of blood supply has become an important means of clinical treatment of cardiovascular and cerebrovascular diseases. At present, stents can be divided into traditional permanent metal stents and new biodegradable stents. Patients using traditional permanent metal stents generally need to take antiplatelet drugs for a long time to prevent the formation of thrombus. However, the stent cannot degrade after completing the supporting function, and long-term stimulation and pulling of the vessel wall will gradually cause in-stent restenosis. Therefore, the researchers proposed a biodegradable stent, which will gradually degrade after providing mechanical support for a period of time according to ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/10A61L31/14C22F3/00
CPCA61L31/022A61L31/10A61L31/148C22F3/00A61L2400/18C08L89/00
Inventor 赵晓杰吴双王云兵秦国双
Owner INNO LASER TECH CORP LTD
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