A method for manufacturing soft curved microfluidic devices based on conformal bonding process

Abstract

The invention belongs to the field of micro-nano manufacturing, and discloses a method for manufacturing a soft curved surface microfluidic device based on a conformal bonding process, comprising the following steps: (1) Preparation of an epoxy resin curved surface microchannel template with a microchannel pattern ; (2) prepare a smooth curved surface microchannel template; (3) cast a silicon rubber film with a microchannel pattern on a curved surface based on two epoxy resin curved surface microchannel templates; (4) coat the surface of the steel or aluminum punch Liquid silicone rubber is heated and cured to form a smooth silicon rubber film with a curved surface; (5) Corona treatment is performed on two silicone rubber films, and they are bonded together and heated to form an irreversible bond, and a microfluidic device with a target microchannel is obtained. The invention can prepare soft curved microfluidic devices, such as microfluidic contact lenses, in which the prepared curved epoxy resin microchannel template can be reused many times, the method is simple and efficient, and can be applied to conformal wearable microfluidics Device preparation.

Description

technical field [0001] The invention belongs to the field of micro-nano manufacturing, and more specifically relates to a method for manufacturing a soft curved microfluidic device based on a conformal bonding process. The method can prepare a soft curved microfluidic device, which is expected to be used in life medicine The field of health diagnosis in China, especially the field of eye health diagnosis mainly based on contact lenses. Background technique [0002] In recent years, wearable microfluidic technology is in the stage of rapid research and development. The current wearable microfluidic devices are all processed by planar technology and have certain flexibility. , bending), chemical (sweat, blood sugar) sensing and drug delivery (insulin), etc. However, at present, planar microfluidic devices cannot be applied to special, fragile, and sensitive three-dimensional curved areas such as the eye cornea, heart, and kidneys. These areas need to conform to their contours...

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Problems solved by technology

[0003] In view of the problem that existing planar microfluidic devices cannot conform to the shape and be applied to complex curved surfaces such as eye corneas, hearts, and kidneys, the purpose of the present invention is to provide a method for manufacturing soft curved surface microfluidic devices based on conformal bonding technology. Through the design of the overall process of the manufacturing method, a soft silicone rubber film with a curved surface containing microchannel patterns is prepared by using silane coupling-assisted bonding, thermoplastic molding, and curved surface inversion. Conformal bonding of the thin film on the surface of the steel ball, and then peeling off to prepare the desired soft curved microfluidic device, the microchannels in the microfluidic device can meet the preset requirements

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