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Anti-tumor drug composition, preparation and application

The technology of an anti-tumor drug and composition, applied in the field of medicine, can solve the problems of undiscovered patent publications and the like, and achieve the effects of significant synergistic curative effect, reduced toxic and side effects, and significant curative effect

Inactive Publication Date: 2019-11-08
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Through the search, no patent publications related to the patent application of the present invention have been found

Method used

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  • Anti-tumor drug composition, preparation and application
  • Anti-tumor drug composition, preparation and application
  • Anti-tumor drug composition, preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The experimental results of vinorelbine and afatinib monomer on the proliferation inhibition of H1975, HCC827 and H460 cells are shown in Table 1, the IC of vinorelbine and afatinib monomer in three kinds of cells 50 The values ​​are shown in the table below.

[0060] Table 1 IC of vinorelbine and afatinib monomer on lung cancer cells 50 value

[0061]

Embodiment 2

[0063] The concentrations in the table were diluted with dimethyl sulfoxide, and the experimental results of the inhibitory effect on proliferation of different concentrations of vinorelbine and afatinib when used alone are shown in Table 2.

[0064] Table 2 The cell inhibition rate and CI value of vinorelbine combined with afatinib on H1975

[0065]

[0066] It can be seen from the above results that when vinorelbine and afatinib are administered at the same time, CI<1, the composition has a good synergistic effect on the inhibition of H1975 cell proliferation.

Embodiment 3

[0068] Diluted with dimethyl sulfoxide to the concentrations in the table, see Table 3 for the experimental results of vinorelbine and afatinib at different concentrations when used alone.

[0069] Table 3 The cell inhibition rate and CI value of vinorelbine combined with afatinib on HCC827

[0070]

[0071] It can be seen from the above results that CI<1 when vinorelbine and afatinib are administered simultaneously, indicating that the composition has a better synergistic effect on HCC827 cells.

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Abstract

The invention relates to an anti-tumor drug composition. The anti-tumor drug composition is prepared from a composition of vinorelbine and afatinib. The combination drugs are used in combination of the vinorelbine and the afatinib. Compared with a single drug, the composition has a remarkable synergistic curative effect on the treatment of a lung cancer, and an in-vitro cell experiment proves thatproliferation of NSCLC cells can be effectively inhibited through the drug combination, a scientific basis is provided for the research and development of novel oncology drugs, and meanwhile, new research ideas are provided for other drug combinations.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to an antitumor drug composition, preparation and application. Background technique [0002] The morbidity and mortality of lung cancer are increasing year by year, and it is the most common cancer in my country. According to the degree of differentiation and morphological characteristics of various types of lung cancer, lung cancer is currently divided into two categories, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), of which 85 % of patients were diagnosed with NSCLC, including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Clinical investigations have shown that most NSCLC patients are already in the middle and advanced stages when they see a doctor, and have lost the best opportunity for surgical treatment, so drug treatment has become their main method. [0003] Chemotherapeutic agent vinorelbine {3',4'-didehydro-4'-deoxy-C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/517A61P35/00A61K31/475
CPCA61K31/475A61K31/517A61P35/00A61K2300/00
Inventor 郁彭刘振滕玉鸥付青山崔丽邱亚楠殷盼盼
Owner TIANJIN UNIV OF SCI & TECH
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