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Method for extracting and separating Eupatorium adenophorum ketone compounds from Eupatorium adenophorum

A technology for zelan and zelanone is applied in the field of extracting and separating zelanone compounds, which can solve the problems of complex method and process, low product purity, complex solvent and the like, and achieves reasonable and feasible process, high product purity and transfer rate. high effect

Active Publication Date: 2019-11-12
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a method for extracting and separating eupholsteron compounds from Eupatorium adenophorum, which solves the problem of complicated process, complex solvent and large consumption, low product purity and low yield in the prior art for extracting and purifying eupholsteron compounds. Low rate and other issues

Method used

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  • Method for extracting and separating Eupatorium adenophorum ketone compounds from Eupatorium adenophorum
  • Method for extracting and separating Eupatorium adenophorum ketone compounds from Eupatorium adenophorum
  • Method for extracting and separating Eupatorium adenophorum ketone compounds from Eupatorium adenophorum

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Embodiment 1

[0032] (1) Medicinal material processing: air-dry in a cool place after collecting Eupatorium adenophorum leaves, and pulverize them to 80-mesh powder with a pulverizer;

[0033] (2) Supercritical CO 2 Extraction: Weigh 1.0Kg of the powder prepared in step (1) and put it in supercritical CO 2 The extraction kettle of the extraction device, the pressure of the extraction kettle is raised to 30MPa, and the temperature is raised to 55°C; the pressure of the analysis kettle I is raised to 18MPa, and the temperature is raised to 50°C; pressure, extraction for 1.0h, after the extraction was completed, the extract from the analysis kettle II was collected to obtain 65.2g of the extract;

[0034] (3) Molecular distillation separation: Take 60.0 g of the extract obtained in step (2), add it to the constant temperature tank of the molecular distillation device, raise the temperature to 150 ° C, adjust the vacuum to 20 Pa, the speed of the scraping film is 250 r / min, and the condensatio...

Embodiment 2

[0038] (1) Medicinal material processing: air-dry in a cool place after collecting Eupatorium adenophorum leaves, and pulverize them to 60-mesh powder with a pulverizer;

[0039] (2) Supercritical CO 2 Extraction: Weigh 1.0Kg of the powder prepared in step (1) and put it in supercritical CO 2 The extraction kettle of the extraction device, the pressure of the extraction kettle is raised to 35MPa, and the temperature is raised to 45°C; the pressure of the analysis kettle I is raised to 21MPa, and the temperature is raised to 45°C; pressure, extraction for 0.5h, after the extraction was completed, the extract from the analysis kettle II was collected to obtain 65.9g of the extract;

[0040] (3) Molecular distillation separation: Take 60.0 g of the extract obtained in step (2), add it to the constant temperature tank of the molecular distillation device, raise the temperature to 200 ° C, adjust the vacuum to 40 Pa, the speed of the scraping film is 300 r / min, and the condensatio...

Embodiment 3

[0043] (1) Medicinal material processing: Collect the leaves of Eupatorium adenophorum and air-dry them in a cool place, and grind them to 120-mesh powder with a pulverizer.

[0044] (2) Supercritical CO 2 Extraction: Weigh 1.0Kg of the powder prepared in step (1) and put it in supercritical CO 2 The extraction kettle of the extraction device, the pressure of the extraction kettle is raised to 25MPa, and the temperature is raised to 65°C; the pressure of the analysis kettle I is raised to 18MPa, and the temperature is raised to 55°C; pressure, extraction for 1.0h, after the extraction was completed, the extract from the analysis kettle II was collected to obtain 64.7g of the extract;

[0045] (3) Molecular distillation separation: Take 60.0 g of the extract obtained in step (2), add it to the constant temperature tank of the molecular distillation device, raise the temperature to 120 ° C, adjust the vacuum to 10 Pa, the speed of the scraping film is 200 r / min, and the condens...

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Abstract

The invention discloses a method for extracting and separating Eupatorium adenophorum compounds from Eupatorium adenophorum. The method comprises the following steps: medicinal material air-drying andcrushing, supercritical CO2 extraction, molecular distillation separation, and industrial chromatographic purification for finally obtaining euptox A and 9-oxoageraphorone. The method has the advantages of high purity of the obtained products, high transfer rate, reasonable and feasible whole technology, simple process, simplicity and easy recovery of a solvent, suitableness for large-batch industrial production, and very strong practical values.

Description

technical field [0001] The invention relates to the technical field of extraction and separation of natural product active ingredients, in particular to a method for extracting and separating eupholsterone compounds from Eupatorium adenophorum. Background technique [0002] Eupatorium adenophorum (Eupatorium adenophorum Spreng) is a perennial semi-shrub herbaceous plant of the genus Eupatorium adenophorum in the family Asteraceae. As a vicious weed, it is now distributed in more than 30 countries in the world and poses a serious threat to the environment. Eupatorium adenophorum has the characteristics of strong adaptability, fast transmission speed, and strong reproductive ability. It forms a single dominant population by repelling the decline of local plants through allelopathy. It was introduced into Yunnan, my country in the 1940s, and was listed as the first foreign invasion in my country. species. It has been widely distributed in Southwest China and has become the most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/78C07C49/637
CPCC07C45/78C07C2602/28C07B2200/07C07C49/637Y02P20/54
Inventor 周雪汪杰葛发欢李海池向安娅
Owner SUN YAT SEN UNIV
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