Multi-spray-head cooperative biological printing method

Abstract

The invention discloses a multi-spray-head cooperative biological printing method. The multi-spray-head cooperative biological printing method comprises the following steps: calibrating spray nozzlesof all spray head assemblies to the origin of a world coordinate system, determining the spray head assembly which needs to perform a printing task, and enabling the spray head assemblies to start theprinting task from the origin in sequence; or enabling the spray head assemblies to sequentially perform the printing task, wherein the task path end point of the last spray nozzle assembly is the task path start point of the next spray head assembly; or enabling all spray head assemblies which perform the printing task to perform on the same printing path, and synchronously starting the printingtask from a zero position along the printing task after all spray head assemblies reach the zero position. The multi-spray-head cooperative biological printing method has the advantages that: the spray head assemblies of the system can cooperatively or sequentially work, so that the printing mode is flexible and various; the tip ends of spray nozzles of the spray head assemblies are washed and cleaned, and stable output, in the normal printing task, of materials is guaranteed; and for peripheral type surrounding temperature control and bottom vacuum adsorbing clamping for a working utensil, mass of a forming living body structure is effectively guaranteed, so that the survival rate of a viable tissue is increased.

Description

technical field [0001] The invention relates to the technical field of biological 3D printing in tissue engineering, in particular to a multi-nozzle collaborative biological printing method of a high-precision biological printing device. Background technique [0002] Every year in the world, an extremely large number of people suffer from various types of injuries leading to tissue defects, or some major diseases require organ transplantation, resulting in a huge demand for tissue and organ repair. For the treatment of damaged large soft tissues and internal organs in the human body, tissue and organ transplantation is an extremely effective treatment method. However, due to the shortage of organ donor sources, immune rejection and other problems, there are insurmountable difficulties in the practical application of organ transplantation. The proposal of tissue engineering has opened up a new way to solve the above problems. Tissue engineering is to attach living cells to ...

AI Technical Summary

Problems solved by technology

For another example, when printing skin, it is necessary to print blood vessels and other tissues. If a single nozzle is used, it will take a long time to replace the nozzle, which will affect the efficiency, and it is also possible that the hydrogel on the other side may be damaged just after the nozzle is replaced. If it is solidified, if multiple infusion channels of the same nozzle are used, it will cause the problem of material mixing at the nozzle; and it cannot be printed at the same time, and the efficiency is lower

[0005] The single nozzle on the market takes envisionTec as an example. Every time the material is changed, the nozzle needs to be moved to the new nozzle, and then the tool is changed by vacuum adsorption, which has the problems of long time and unguaranteed positioning accuracy.

In addition, if there are gaps between the 6 blocks when printing a discrete hexagonal shape similar to liver cells, there will be longer wiring; this severely limits the ability to print complex organs, and the printing time is too long and the efficiency is low

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