AIE carbon quantum dots and preparation method and application thereof

Abstract

The invention relates to AIE carbon quantum dots and a preparation method and application thereof. In the preparation method, a micro-fluidic chip is used and comprises a first liquid inlet, a secondliquid inlet, a third liquid inlet, a mixing passage and a liquid outlet; the preparation method comprises the following steps that a mixed AIE molecule and phospholipid solution flows into the micro-fluidic chip through the third liquid inlet, water flows into the micro-fluidic chip through the first liquid inlet and the second liquid inlet, the mixed solution and the water flow through the mixing passage, and the AIE carbon quantum dots are obtained at the liquid outlet. Through the method that AIE molecules and phospholipid are premixed first and then introduced into the micro-fluidic chip,the AIE carbon quantum dots of which the average diameter is smaller than or equal to 10 nanometers can be prepared, and the problem is solved that a large number of large AIE dots accumulate to theliver in vivo, so that target missing is caused.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to an AIE carbon quantum dot and its preparation method and application. Background technique [0002] Aggregation-induced emission (AIE) refers to the phenomenon that the fluorescence of a fluorophore is greatly enhanced when it is in an aggregated state. These fluorophores contain rotatable groups, such as peripheral phenyl groups linked by carbon-carbon single bonds. AIE monomer molecules tend to be highly hydrophobic. Through ultrasonic or microfluidic mixing, hydrophobic AIE monomer molecules and amphiphilic phospholipid molecules can form AIE core / phospholipid shell thermodynamically stable nanoparticles, also called AIE dots. However, whether it is ultrasonic or microfluidic mixing, the smallest size that can be achieved by AIE points is still higher than 30nm. AIE points above 30nm will be taken up by the reticuloendothelial system in the body and accumulate in the ...

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Problems solved by technology

However, the minimum particle size of the AIE nanoparticles prepared by the method of the invention is 58nm, and the size is relatively large, which is easy to accumulate in the liver in large quantities, affecting the imaging effect or curative effect, and causing a burden on the liver.

[0006] Therefore, there is an urgent need in this field to study a method that can prepare AIE dots with smaller particle sizes, so as to solve the off-target problem of large AIE dots accumulating in the liver in large quantities

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