Gegen-qinlian decoction water extract for regulating obese body
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A technology of Gegen Qinlian Decoction and water extract, which is applied in the field of traditional Chinese medicine, can solve the problems of lack of reports and achieve the effects of reducing lipid metabolism, changing energy metabolism, preventing obesity and insulin resistance
Inactive Publication Date: 2019-11-19
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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[0006] The technical problem to be solved by the present invention is: to regulate the expression level of intestinal flora and liver circadian clock gene of pre-diabetic obesity disease through the water extract of Gegen Qinlian Decoction, and then study and treat pre-diabetic obesity disease, there is still a lack of related reports and other defects and deficiencies, this technology provides a water extract of Gegen Qinlian Decoction for regulating intestinal dampness and heat of obese body and regulating liver biological clock gene expression level and its application
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Embodiment 1
[0033] Example 1: Preparation of Gegen Qinlian Decoction Water Extract Oral Liquid
[0034] Compatibility of medicinal materials: 8 parts of Pueraria lobata, 3 parts of Scutellaria baicalensis, 3 parts of Coptis chinensis, and 2 parts of roasted licorice in terms of mass parts.
[0035] Add water for soaking: Take 1 kg of the above-mentioned medicinal materials that have been weighed and compatible, add 8 kg of clean water according to the water ratio of 1:8, add water and soak for 30-60 minutes;
[0036] Heating and decocting: Heat the above-mentioned soaked medicinal materials and soaking water to boiling, keep decocting for 30-60 minutes and filter to obtain the decoction filtrate, repeat the decoction once, and combine the decoction filtrate;
[0037] Concentration under reduced pressure: Concentrate the above-mentioned combined decoction filtrate under a vacuum condition of ≤-0.08MPa at low temperature until the volume of the concentrated solution is 1 liter, and the conc...
Embodiment 2
[0039] Example 2: Animal experiments for regulating the intestinal flora of obese organisms
[0040] 1. Experimental plan
[0041] A total of 90 rats in this batch were randomly divided into blank group and obesity model group. The blank group was fed with common feed containing 10% fat, and the model group was fed with high-fat feed containing 60% fat. , continue to use the modeling control group (Control, referred to as C), given ordinary feed. According to body weight, the model group was randomly divided into obesity model group (OB), GQD high-dose group (HD), GQD medium-dose group (MD), GQD low-dose group (LD), simvastatin group (SIM), 15 Only, give high-fat feed. The administration group calculated the dosage per kilogram of rat body weight, and performed intragastric administration once a day until 17 weeks. The specific administration of each group of animals is as follows, the following is the dose given per kilogram of rat body weight:
[0042] Simvastatin group ...
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Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a gegen-qinlian decoction water extract for regulating an obese body. The gegen-qinlian decoction waterextract is obtained from puerarin, radix scutellariae, coptidis rhizome and radix liquiritiae through medicinal material compatibility and water decoction; the medicinal material compatibility is calculated by the following materials in parts by mass: 7-9 parts of the puerarin, 2-4 parts of the radix scutellariae, 2-4 parts of the coptidis rhizome, and 1-3 parts of the radix liquiritiae; the gegen-qinlian decoction water extract is used for preparing drugs to regulate intestinal flora and liver biological clock genes of intestine damp heat of the obese body, and has the effect of reversing Akkermansia and Lactobacillus, at the same time, the expression and transcription level of liver Clock and Arntl genes is up-regulated, the level of body serum triglyceride can be effectively reduced, and the gegen-qinlian decoction water extract has a regulatory effect on total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood glucose, insulin and other blood lipid and blood glucose indexes, and also has a regulatory effect on short chain, medium chain and long chain fatty acids, tryptophan, kynurenine, cannabinoid and other metabolites of the body.
Description
technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, in particular to a water extract of Gegen Qinlian Decoction used for regulating obese body, in particular to an intestinal flora used for regulating intestinal dampness and heat of obese body Akkermansia , Lactobacillus and liver clock genes Clock , Arntl Water extract of Gegen Qinlian Decoction. Background technique [0002] Almost all organisms, from single-celled bacteria to plants and animals, exhibit behavioral, physiological, and biochemical rhythms that are close to the time of the earth's rotation, ie, approximately 24-h circadian rhythms. The biological clock is mainly regulated by signals from the surrounding environment, such as light, food intake, temperature, and humidity. In higher multicellular organisms, biological clocks can be divided into master clocks (main biological clocks) and secondary clocks (peripheral biological clocks). The physiological sys...
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