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Compound propranolol hydrochloride oral liquid for treating infantile hemangiomas

A technology of compound propranolol hydrochloride oral liquid and propranolol hydrochloride, which is applied in the field of medicine, can solve the problems of poor effect and large side effects of hemangioma in children, and achieve small dosage, good bioavailability, quality and effect Improved effect

Active Publication Date: 2019-11-19
河南百年康鑫药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For above-mentioned situation, in order to overcome the defective of prior art, the object of the present invention is to provide a kind of compound propranolol hydrochloride oral liquid for the treatment of infantile hemangioma, can effectively solve the problem that the side effect of treatment infantile hemangioma is big, and effect is poor

Method used

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  • Compound propranolol hydrochloride oral liquid for treating infantile hemangiomas
  • Compound propranolol hydrochloride oral liquid for treating infantile hemangiomas

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A compound propranolol hydrochloride oral liquid for treating infantile hemangioma, comprising the following raw materials by weight: 200 g of gallinaceous gold, 300 g of hawthorn, 200 g of snakeberry, 250 g of purple pearl leaves, 300 g of salvia miltiorrhiza, 200 g of lotus leaves and propranolium hydrochloride Lol 40g;

[0016] Among them: (1) Put the six raw materials of gallinacea, hawthorn, snakeberry, purple pearl leaf, salvia miltiorrhiza and lotus leaf into the extraction tank, add water until the raw materials are covered, soak at 50°C for 45 minutes, heat to boiling, Decocting twice, adding water 10 times the weight of the Liuwei raw material each time, decocting for 1.5 hours each time, filtering, combining the two filtrates, and concentrating to the first extract with a relative density of 1.25 at 70°C;

[0017] (2) Add ethanol with a volume concentration of 90% to the first extract and mix well, so that the volume of alcohol in the mixture of the first ext...

Embodiment 2

[0021] A compound propranolol hydrochloride oral liquid for treating infantile hemangioma, comprising the following raw materials by weight: 100 g of gallinaceous gold, 200 g of hawthorn, 100 g of snakeberry, 200 g of purple pearl leaves, 200 g of salvia miltiorrhiza, 100 g of lotus leaves and propranolium hydrochloride Lol 30g;

[0022] Among them: (1) Put the six raw materials of gallinarum, hawthorn, snakeberry, purple pearl leaf, salvia miltiorrhiza and lotus leaf into the extraction tank, add water until the raw materials are covered, soak at 45°C for 30 minutes, heat to boiling, Decocting twice, adding water 8 times the weight of the six-flavored raw material each time, decocting for 1 hour each time, filtering, combining the two filtrates, and concentrating to the first extract with a relative density of 1.15 at 65°C;

[0023] (2) Add ethanol with a volume concentration of 80% to the first extract and mix evenly, so that the volume of alcohol in the mixture of the first...

Embodiment 3

[0027] A compound propranolol hydrochloride oral liquid for treating infantile hemangioma, comprising the following raw materials by weight: 300 g of gallinaceous gold, 400 g of hawthorn, 300 g of snakeberry, 300 g of purple pearl leaves, 400 g of salvia miltiorrhiza, 300 g of lotus leaves and propranolium hydrochloride Lol 50g;

[0028] Among them: (1) Put the six raw materials of gallinacea, hawthorn, snakeberry, purple pearl leaf, salvia miltiorrhiza and lotus leaf into the extraction tank, add water until the raw materials are covered, soak at 55°C for 60 minutes, heat to boiling, Decocting twice, each time adding 12 times the weight of the Liuwei raw material medicine, decocting for 2 hours each time, filtering, combining the two filtrates, and concentrating to the first extract with a relative density of 1.35 at 75°C;

[0029](2) Add ethanol with a volume concentration of 95% to the first extract and mix evenly, so that the volume of alcohol in the mixture of the first e...

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Abstract

The invention relates to compound propranolol hydrochloride oral liquid for treating infantile hemangiomas. The compound propranolol hydrochloride oral liquid comprises the following raw materials byweight of 100-300g of endothelium corneum gigeriae galli, 200-400g of haws, 100-300g of duchesnea indica, 200-300g of bigleaf beautyberry leaves, 200-400g of radix salviae miltiorrhizae, 100-300g of lotus leaves and 30-50g of propranolol hydrochloride. Compared with the prior art, the compound propranolol hydrochloride oral liquid disclosed by the invention has the advantages that the quality andthe effects are notably improved, and the compound propranolol hydrochloride oral liquid is high in cure rate, low in adverse reaction rate, good in mouth feel, easy in infantile administration, smallin dosage and good in biological availability and have enormous social and economic benefits.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound propranolol hydrochloride oral liquid for treating infantile hemangioma. Background technique [0002] Infantile hemangiomas (IH) are the most common benign tumors in children. According to literature reports, the incidence of common neonatal hemangiomas is 1.1% to 2.6%, and premature infants can reach 10% or even higher. The rate is three times that of boys. Hemangiomas are embryonic benign neoplastic deformities with biological characteristics of vascular endothelial cell proliferation and natural regression after proliferation. Clinically, infantile hemangiomas are mainly manifested in two completely different stages—— Proliferative phase and regressive phase, IH may not be obvious at birth, but enters the proliferative phase shortly after birth, its initial clinical manifestations are small red plaques or papules, and in the following 6 months to 1 year The tumor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K9/08A61P35/00A61K31/138A61K35/57
CPCA61K9/0095A61K31/138A61K35/57A61K36/537A61K36/62A61K36/73A61K36/734A61K36/85A61K47/26A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P35/00A61K2300/00
Inventor 王粉王军政蔡俊安
Owner 河南百年康鑫药业有限公司
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