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A kind of composite nanofiber membrane and its preparation method and application

A technology of composite nanofibers and preparation steps, which can be used in drug combinations, pharmaceutical formulations, textiles and papermaking, etc. It can solve the problems of unsatisfactory research results, achieve controlled release, and inhibit the proliferation of ocular fibroblasts.

Active Publication Date: 2022-02-15
PEOPLES HOSPITAL OF HENAN PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, ophthalmologists have conducted a lot of research. They have repeatedly injected 5-fluorouracil (5-FU) under the conjunctiva to reduce the recurrence rate after pterygium surgery and reduce the scarring of the filtering channel after anti-glaucoma surgery. Metabolism, study results are less than promising

Method used

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  • A kind of composite nanofiber membrane and its preparation method and application
  • A kind of composite nanofiber membrane and its preparation method and application
  • A kind of composite nanofiber membrane and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of a composite nanofibrous membrane, the preparation steps are as follows:

[0023] (1) Preparation of spinning solution: Dissolve 10 mg of 5-fluorouracil, 10 mg of chitosan, and 90 mg of silk protein in 1 mL of a mixed solution consisting of hexafluoroisopropanol and formic acid at a volume ratio of 9:1;

[0024] (2) Electrospinning: The spinning solution obtained in step (1) was subjected to electrospinning at a speed of 0.8 mL / h, a voltage of 15 kV, and a receiving distance of 20 cm to obtain a composite nanofibrous membrane.

[0025] The SEM image of the resulting composite nanofibrous membrane is shown in figure 1 .

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Abstract

The invention belongs to the technical field of drug sustained-release carriers, and discloses a composite nanofiber membrane, a preparation method and application thereof. The preparation steps are as follows: (1). Preparation of spinning solution: dissolving 5-fluorouracil and biological materials in an organic solvent to prepare a spinning solution with a solid content concentration of 6-15 wt%. (2). Electrospinning: dissolving The spinning solution was subjected to electrospinning under the conditions of a spinning solution advancing speed of 0.1-2.5 mL / h, a voltage of 5-25 kV, and a receiving distance of 5-25 cm to obtain a composite nanofiber membrane. The invention uses an electrospinning process to spin 5-fluorouracil on biological materials to prepare a composite nanofiber film, which can realize the controlled release of drugs and obviously inhibit the proliferation of ocular fibroblasts.

Description

technical field [0001] The invention belongs to the technical field of drug sustained-release carriers, and in particular relates to a composite nanofiber membrane and its preparation method and application. Background technique [0002] The proliferation of fibroblasts in the ocular subconjunctiva is the main cause of postoperative tissue fibrosis. The proliferation of fibroblasts after pterygium surgery makes the recurrence rate of pterygium surgery as high as 40%. The recurrence after pterygium surgery can cause symblephagy and conjunctival sac narrowing, which seriously affects vision and eye movement; excessive fibroblasts Proliferation, also responsible for post-filtration scarring in glaucoma, the second most blinding eye disease, leads to a 1-year failure rate of up to 15% after anti-glaucoma surgery. In patients with ocular chemical injury, the extensive proliferation of fibroblasts in the subconjunctiva causes symblephane and conjunctival sac constriction, and the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/728D04H1/4382A61K9/70A61K31/513A61K47/36A61K47/32A61K47/34A61K47/42A61P27/02
CPCD04H1/728D04H1/4382A61K9/7007A61K9/0002A61K31/513A61K47/36A61K47/32A61K47/34A61K47/42A61P27/02
Inventor 栗占荣靳林李景果祝磊郭志华石刘奇储丹丹韩奉奇
Owner PEOPLES HOSPITAL OF HENAN PROV