Use of short chain fatty acids for treatment and prevention of diseases and disorders
A fatty acid and disease technology, applied in skin diseases, sensory diseases, allergic diseases, etc., can solve problems such as rapid absorption and short half-life
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[0260] The invention includes pharmaceutical compositions comprising one or more compositions of the invention. Formulations of the pharmaceutical compositions described herein may be prepared by any method known or hereafter developed in the art of pharmacology. In general, these methods of preparation include the step of bringing into association the active ingredient with the carrier or one or more other accessory ingredients, and then, if necessary or desirable, shaping or packaging the product into desired unit-dose or multi-dose units.
[0261] Depending on the intended use and application, the composition may contain additional medicinal agents, pharmaceutical agents, carriers, buffers, adjuvants, dispersants, diluents, and the like.
[0262] Examples of suitable pharmaceutical carriers, excipients and / or diluents are well known in the art and include, but are not limited to, gums, starches (e.g., cornstarch, pregelatinized starch), sugars (e.g., lactose, mannitol, sucr...
example 1
[0351] Example 1: Treatment of Skin Disorders with Short Chain Fatty Acids
[0352] Psoriasis is a chronic autoinflammatory disease that causes raised, red, scaly plaques on the skin. It usually affects the outside of the elbow, knee, or scalp, but it can appear anywhere. Some people report psoriasis as itching, burning, and stinging. Psoriasis has been linked to other serious health conditions, such as diabetes, heart disease, and depression.
[0353] Current treatments for psoriasis include topical (creams, ointments, and light therapy) and systemic (oral and injectable medications) therapies. Topical creams and ointments include corticosteroids (overuse can lead to skin thinning and resistance), retinoids, anthralin (normalizes skin cell growth), and vitamin D analogs (retinoids, anthralin, or vitamin D analog therapy can irritate the skin), calcineurin inhibitors (disrupt T-cell activation, continued use is associated with increased risk of skin cancer and lymphoma), ...
example 2
[0375] Example 2: Treatment of Skin Disorders Using Combinations of Short Chain Fatty Acids
[0376] This example is based in part on the discovery that administration of at least one SCFA in combination with at least one second compound is an effective method of treating skin diseases and disorders, including psoriasis. Without being bound by theory, it is expected that the combination of at least one SCFA and at least one second compound will provide effective treatment of skin disorders. Additional compounds contemplated for use include PDE4 inhibitors, anti-inflammatory compounds, disease-modifying antirheumatic drugs (DMARDs), immunosuppressants, biologics, Cox-2 inhibitors, apremilast, or combinations thereof, and / or another medicine. Non-limiting examples of these and other compounds useful in the present invention are provided above.
[0377] Suggested treatment:
[0378] Combination therapy with apremilast: daily oral dose of 1g-2g butyrate, 100mg propionate, ...
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Abstract
Description
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