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Preparation method of sophocarpidine

A technology of matrine and ginseng liquid, which is applied in the field of preparation of matrine, can solve the problems of many impurities in the extract, high yield of total alkaloids of matrine, poor extraction effect, etc., and achieve less residue and low cost , the effect of improving the purity

Inactive Publication Date: 2019-11-22
孙伟年
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the traditional extraction method, the yield of total alkaloids of Sophora flavescens is high, that is, there are more impurities in the obtained extract, and the extraction effect is poor
[0005] With other extraction techniques, the content of matrine in the extracted matrine raw powder is often less than 50%, and the extraction effect is also poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] A preparation method of matrine, comprising the following steps:

[0031] 1) Wash the raw materials for making matrine and put them into a glass vessel filled with sodium chloride solution. The positive and negative electrodes of the pulse stimulator are respectively located in the sodium chloride solution at both ends of the glass vessel. Finally, turn off the pulse stimulator, take out the raw materials, wash and dry them;

[0032] 2) The dried raw materials are crushed to 20-30 meshes and then mixed with water to obtain a primary raw material liquid with a dry-wet ratio of 1-2:0.6-3.5;

[0033] 3) Grinding the primary raw material liquid until the particle size thereof is less than 100 microns to obtain an intermediate raw material liquid;

[0034] 4) The intermediate raw material liquid is subjected to CO 2 Supercritical extraction, followed by separation by a separator twice, and spray drying to obtain matrine raw powder with a content greater than 50% and less t...

Embodiment 1

[0050] 1) Wash the raw materials for making matrine and put them into a glass vessel filled with sodium chloride solution. The positive and negative electrodes of the pulse stimulator are respectively located in the sodium chloride solution at both ends of the glass vessel. Finally, turn off the pulse stimulator, take out the raw materials, wash and dry them;

[0051] 2) The dried raw materials are crushed to 20 mesh and then mixed with water to obtain primary raw material liquid with a dry-wet ratio of 1:0.6;

[0052] 3) Grinding the primary raw material liquid until the particle size thereof is less than 100 microns to obtain an intermediate raw material liquid;

[0053] 4) The intermediate raw material liquid is subjected to CO 2Supercritical extraction, followed by separation by a separator twice, and spray drying, the content of matrine in the obtained matrine raw powder is 68%.

[0054] It also includes step 5) mixing the original matrine powder with water to obtain ma...

Embodiment 2

[0064] 1) Wash the raw materials for making matrine and put them into a glass vessel filled with sodium chloride solution. The positive and negative electrodes of the pulse stimulator are respectively located in the sodium chloride solution at both ends of the glass vessel. Finally, turn off the pulse stimulator, take out the raw materials, wash and dry them;

[0065] 2) The dried raw materials are crushed, crushed to 30 meshes, and mixed with water to obtain a primary raw material liquid with a dry-wet ratio of 2:3.5;

[0066] 3) Grinding the primary raw material liquid until the particle size thereof is less than 100 microns to obtain an intermediate raw material liquid;

[0067] 4) The intermediate raw material liquid is subjected to CO 2 Supercritical extraction, followed by separation by a separator twice, and spray drying, the content of matrine in the obtained matrine raw powder is 72%.

[0068] As a preferred technical solution, it also includes step 5) mixing the or...

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Abstract

The invention discloses a preparation method of sophocarpidine. The method comprises the following steps: 1) cleaning raw materials for preparing sophocarpidine, putting the cleaned raw materials intoa glassware filled with a sodium chloride solution, respectively positioning positive and negative electrode plates of a pulse stimulator in the sodium chloride solution at two ends in the glassware,closing the pulse stimulator after pulse current stimulation, taking out the raw materials, cleaning and drying in the sun; 2) crushing the sun-dried raw materials to 20-30 meshes, and mixing the crushed raw materials with water to obtain a primary raw material solution with a dry-wet ratio of (1-2): (0.6-3.5); 3) grinding the primary raw material solution until the particle size is less than 100microns to obtain an intermediate raw material solution; and 4) carrying out CO2 supercritical extraction on the intermediate raw material solution, separating twice by a separator, and carrying outspray drying to obtain matrine raw powder with the content of more than 50% and less than 75%. The method has the advantages of simple process, low cost, convenience in operation, low consumption, high efficiency and rapidness in production of high-purity matrine.

Description

technical field [0001] The invention relates to the technical field of medicine extraction, in particular to a preparation method of matrine. Background technique [0002] The traditional Chinese medicine Sophora flavescens is the dried root of the leguminous plant Sophors flavescens Ait. It is bitter in taste, cold in nature, has the functions of clearing away dampness and dampness, and killing insects. It is clinically used to treat dysentery, jaundice and skin itching. In recent years, it has also been found to have pharmacological effects such as anti-tumor and whitening. [0003] Sophora flavescens mainly contains alkaloids such as matrine and oxymatrine. Among them, matrine is a natural active substance that has a significant health care effect on human health. It has attracted widespread attention from the international community. It has been proved by scientific research and clinical application that matrine has anti-tumor, white blood cell increase, asthma and expe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/22B82Y5/00A01N43/90A01P7/04
CPCA01N43/90B82Y5/00C07D471/22Y02P20/54
Inventor 孙伟年
Owner 孙伟年
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