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Method for simultaneously obtaining T1 weighted imaging by using RAREVTR sequence aiming at magnetic resonance double-signal nano probe

A technology of nanoprobe and imaging method, which is applied in the direction of measurement, magnetic resonance measurement, diagnosis signal processing, etc. using nuclear magnetic resonance imaging system, and can solve problems such as the effect of aliasing signals

Active Publication Date: 2019-11-26
HARBIN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the influence of confusing signals that occur during the imaging of the existing ParaVision6.0.1 imaging system RAREVTR sequence (the sequence used for T1mapping imaging) T1, T2 dual-signal probes, and achieve T1 while obtaining conventional T1 values ​​through parameter optimization weighted image

Method used

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  • Method for simultaneously obtaining T1 weighted imaging by using RAREVTR sequence aiming at magnetic resonance double-signal nano probe
  • Method for simultaneously obtaining T1 weighted imaging by using RAREVTR sequence aiming at magnetic resonance double-signal nano probe
  • Method for simultaneously obtaining T1 weighted imaging by using RAREVTR sequence aiming at magnetic resonance double-signal nano probe

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Embodiment 1

[0040] Example 1: In order to eliminate the influence of T2 aliasing signals and realize T1 weighted imaging, the maximum TR is set to be less than 1 / 5 T1 value on the basis of the original imaging sequence parameters, and T1 is the longitudinal relaxation time of the probe solution.

Embodiment 2

[0041] Embodiment 2: In order to eliminate the influence of T2 confusing signal, realize T1 weighted imaging, on the basis of original imaging sequence parameters, TE is set to be less than 1 / 5T2; Maximum TR is set to be less than 1 / 5T1 value, and described T1 is probe solution Longitudinal relaxation time, T2 is the transverse relaxation time of the probe solution.

Embodiment 3

[0042] Example 3: In order to eliminate the influence of T2 aliasing signals, T1 weighted imaging is realized. On the basis of the original imaging sequence parameters, TE is set to be less than 1 / 5T2; TR is set to multiple values, the maximum value is 4000ms, and T1 is the probe The longitudinal relaxation time of the solution, T2 is the transverse relaxation time of the probe solution.

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Abstract

The invention relates to the technical field of optimization of medical imaging sequence parameters, in particular to a method for simultaneously obtaining T1 weighted imaging by using a RAREVTR sequence aiming at a magnetic resonance double-signal nano probe. The method comprises the following steps of: (1) preparing nano probes with T1 and T2 double contrast signals at different concentrations,wherein the concentrations are 0.05 mM, 0.1 mM, 0.2 mM and 0.4 mM respectively; (2) fixing the matched probes together, placing the probes in a magnet middle scanning bed, performing tuning, and thenscanning RAREVTR and MSME sequences on a ParaVision6.0.1 imaging system conventionally to obtain T1 values and T2 values corresponding to the probes with different concentrations; and (3) after the step (2), setting the optimum TE value and TR value for a probe solution according to Y=[A+C * (1-exp (-TR / T1))] * exp (-TE / T2) equation. When the double-signal probe T1mapping imaging is performed, the RAREVTR sequence with optimized parameters can eliminate the influence of the probe T2 signal. When the double-signal probe T2mapping imaging is performed, the MSME sequence with optimized parameters can eliminate the influence of the probe T1 signal. The RAREVTR sequence with optimized parameters can obtain both accurate T1 value and approximate T1WI image.

Description

technical field [0001] The present invention relates to the technical field of optimization of medical imaging sequence parameters, that is, a method for simultaneously obtaining T1 (longitudinal relaxation time) weighted imaging method for magnetic resonance dual-signal nanoprobes using RAREVTR (multi-repetition time rapid spin echo) sequence, specifically Bruker 9.4T (9.4 Tesla) small animal nuclear magnetic resonance (BioSpec94 / 20USR) ParaVision6.0.1 system uses RAREVTR sequence for imaging of dual-signal nanoprobes while eliminating the influence of T2 (transverse relaxation time) aliasing signals while achieving T1 Method of Weighted Imaging. Background technique [0002] In the existing technology, magnetic resonance imaging (magnetic resonance imaging, MRI) is an imaging technology that combines the advantages of non-invasive scanning and high-resolution images in the field of medical imaging. It is an intersectional technology with broad prospects in disease-related...

Claims

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Application Information

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IPC IPC(8): A61B5/055
CPCA61B5/055A61B5/72G01R33/5601G01R33/50G01R33/58G01R33/5602G01R33/5617
Inventor 孙夕林王凯阿荣杨丽丽姜萌姜炜琪乔文菊孙晓红程立欣
Owner HARBIN MEDICAL UNIVERSITY
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