A Method for Simultaneous T1-weighted Imaging Using RareVTR Sequences for Magnetic Resonance Dual-signal Nanoprobes

Abstract

The invention relates to the technical field of optimization of medical imaging sequence parameters, that is, a method for simultaneously obtaining T1 weighted imaging by using a RAREVTR sequence for magnetic resonance double-signal nanoprobes. The steps are as follows: (1) Nano-probes with T1 and T2 double contrast signals are equipped with different concentrations, the concentrations are respectively 0.05mM, 0.1mM, 0.2mM, and 0.4mM. (2) The prepared probe phantom is fixed together, placed on the scanning bed in the middle of the magnet and tuned, and then the RAREVTR and MSME sequences are routinely scanned on the ParaVision6.0.1 imaging system to obtain the T1 and T2 values ​​corresponding to different concentrations of probes. (3) After step (2), set the optimal TE value and TR value for the probe solution according to the equation Y=[A+C*(1‑exp(‑TR / T1))]*exp(‑TE / T2) . When imaging with dual-signal probe T1mapping, the RAREVTR sequence with optimized parameters can eliminate the influence of probe T2 signal. When the dual-signal probe T2mapping is used for imaging, the optimized MSME sequence can eliminate the influence of the probe T1 signal. The RAREVTR sequence with optimized parameters can obtain not only accurate T1 values ​​but also approximate T1WI images.

Description

technical field [0001] The present invention relates to the technical field of optimization of medical imaging sequence parameters, that is, a method for simultaneously obtaining T1 (longitudinal relaxation time) weighted imaging method for magnetic resonance dual-signal nanoprobes using RAREVTR (multi-repetition time rapid spin echo) sequence, specifically Bruker 9.4T (9.4 Tesla) small animal nuclear magnetic resonance (BioSpec94 / 20USR) ParaVision6.0.1 system uses RAREVTR sequence for imaging of dual-signal nanoprobes while eliminating the influence of T2 (transverse relaxation time) aliasing signals while achieving T1 Method of Weighted Imaging. Background technique [0002] In the existing technology, magnetic resonance imaging (magnetic resonance imaging, MRI) is an imaging technology that combines the advantages of non-invasive scanning and high-resolution images in the field of medical imaging. It is an intersectional technology with broad prospects in disease-related...

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Problems solved by technology

[0005] The purpose of the present invention is to solve the influence of confusing signals that occur during the imaging of the existing ParaVision6.0.1 imaging system RAREVTR sequence (the sequence used for T1mapping imaging) T1, T2 dual-signal probes, and achieve T1 while obtaining conventional T1 values ​​through parameter optimization weighted image

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