A Method for Simultaneous T1-weighted Imaging Using RareVTR Sequences for Magnetic Resonance Dual-signal Nanoprobes

A nano-probe and dual-signal technology, which is applied in the directions of using nuclear magnetic resonance image system for measurement, magnetic resonance measurement, and diagnostic signal processing, etc., and can solve problems such as the influence of confusing signals
CN110495887BActive Publication Date: 2022-02-15HARBIN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HARBIN MEDICAL UNIVERSITY
Publication Date
2022-02-15

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Abstract

The invention relates to the technical field of optimization of medical imaging sequence parameters, that is, a method for simultaneously obtaining T1 weighted imaging by using a RAREVTR sequence for magnetic resonance double-signal nanoprobes. The steps are as follows: (1) Nano-probes with T1 and T2 double contrast signals are equipped with different concentrations, the concentrations are respectively 0.05mM, 0.1mM, 0.2mM, and 0.4mM. (2) The prepared probe phantom is fixed together, placed on the scanning bed in the middle of the magnet and tuned, and then the RAREVTR and MSME sequences are routinely scanned on the ParaVision6.0.1 imaging system to obtain the T1 and T2 values ​​corresponding to different concentrations of probes. (3) After step (2), set the optimal TE value and TR value for the probe solution according to the equation Y=[A+C*(1‑exp(‑TR / T1))]*exp(‑TE / T2) . When imaging with dual-signal probe T1mapping, the RAREVTR sequence with optimized parameters can eliminate the influence of probe T2 signal. When the dual-signal probe T2mapping is used for imaging, the optimized MSME sequence can eliminate the influence of the probe T1 signal. The RAREVTR sequence with optimized parameters can obtain not only accurate T1 values ​​but also approximate T1WI images.
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Description

technical field

[0001] The present invention relates to the technical field of optimization of medical imaging sequence parameters, that is, a method for simultaneously obtaining T1 (longitudinal relaxation time) weighted imaging method for magnetic resonance dual-signal nanoprobes using RAREVTR (multi-repetition time rapid spin echo) sequence, specifically Bruker 9.4T (9.4 Tesla) small animal nuclear magnetic resonance (BioSpec94 / 20USR) ParaVision6.0.1 system uses RAREVTR sequence for imaging of dual-signal nanoprobes while eliminating the influence of T2 (transverse relaxation time) aliasing signals while achieving T1 Method of Weighted Imaging. Background technique

[0002] In the existing technology, magnetic resonance imaging (magnetic resonance imaging, MRI) is an imaging technology that combines the advantages of non-invasive scanning and high-resolution images in the field of medical imaging. It is an intersectional technology with broad prospects in disease-related...

Claims

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