Method for determining content of glucose in compound electrolyte glucose injection

A technology of glucose injection and compound electrolyte, which is applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve problems such as undocumented, and achieve the effects of improving quality control, realizing separation, and simple and feasible determination methods.
CN110531003AInactive Publication Date: 2019-12-03CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2019-12-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for determining the content of glucose in a compound electrolyte glucose injection. The method comprises the following steps of (1) preparing a reference substance solution, namely weighing a glucose standard substance, adding ultrapure water to dissolve, dilute and uniformly shake to obtain the reference substance solution, (2) preparing a test sample solution, namely measuring and taking the compound electrolyte glucose injection, adding ultrapure water to dilute and shake uniformly to obtain the test sample solution, wherein the ratio of the concentration ofglucose in the reference substance solution in the step (1) to the concentration of glucose in the test sample solution is 1 to 1, and (3) detecting and reading the chromatographic peak areas of thereference substance solution and the test sample solution through a high-performance liquid chromatographic instrument and calculating the glucose concentration by combining the concentration of the reference substance solution and adopting an external standard method. The method has the advantages of high measurement precision and simple and convenient operation.
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Description

technical field

[0001] The invention relates to a method for measuring glucose content, in particular to a method for measuring glucose content in compound electrolyte glucose injection. Background technique

[0002] At present, the method for determining the content of glucose in the compound electrolyte glucose MG3 injection has the optical rotation method, which is to determine the glucose content in the compound preparation by the optical rotation of the sample to be tested and the known specific optical rotation of the pure substance. This method is harmful to the environment. The temperature control requirements are high, and the determination is easily affected by environmental factors; secondly, when the preparation contains multiple compounds with optical activity, the optical polarimetry method cannot accurately determine the content of glucose. Many compound glucose preparations currently on the market contain two or more compounds with optical activity at the sam...

Claims

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