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Gene-ATF4 capable of retarding blood pressure rise in high-salt induced mice

One-ATF4, ATF4 technology, applied in the field of medicine

Pending Publication Date: 2019-12-03
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no studies have shown that ATF4 may be involved in the formation of hypertension

Method used

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  • Gene-ATF4 capable of retarding blood pressure rise in high-salt induced mice
  • Gene-ATF4 capable of retarding blood pressure rise in high-salt induced mice
  • Gene-ATF4 capable of retarding blood pressure rise in high-salt induced mice

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0045] combine figure 1 , figure 2 , image 3 with Figure 4 , Experimental animals: ATF4 gene knockout or knockdown C57BL / 6J mice were purchased from Nanjing Institute of Animal Modeling, wild-type C57BL / 6J mice were purchased from the Animal Center of Southern Medical University, and were raised in the SPF level barrier of the Experimental Animal Management Center of Jinan University environment.

[0046] Animal grouping: 18 ATF4 gene knockout or knockdown C57BL / 6J strain mice, 18 wild-type mice. Divided into gene knockout + normal diet group (KO-NS: 6 rats), gene knockout + 8% high-salt diet group (KO-HS: 12 rats), wild type + normal diet group (WT-NS: 6 rats ), wild type+8% high-salt diet group (WT-HS: 12 rats).

[0047] Modeling method: WT-NS group and KO-NS group were fed with normal mouse feed, WT-HS group and KO-HS group were fed with 8% high-salt feed customized by Nantong Trofee Company, free to eat and drink during the period , fed for 28 days; on the 29th da...

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Abstract

The invention discloses a gene-ATF4 capable of retarding blood pressure rise in high-salt induced mice and relates to the field of medical technologies. According to the function of the gene-ATF4 capable of retarding the blood pressure rise in the high-salt induced mice on high blood pressure of the high-salt induced mice, it is discovered that the blood pressure rise in the high-salt induced micecan be retarded by knocking the ATF4 out or down, and blood vessels are protected by knocking the gene-ATF4 out or down.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a gene-ATF4 capable of blocking high-salt-induced elevation in mice. Background technique [0002] Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by damage to target organs such as the heart, brain, kidneys, and blood vessels. Controlling the occurrence and development of hypertension has become an important issue to be solved urgently. Vascular endothelial cells have a highly developed endoplasmic reticulum, which is an organelle for endothelial / secretory protein synthesis. It plays an important role in regulating protein folding, calcium homeostasis, and cell apoptosis. It is an important factor for maintaining vascular endothelial function. subcellular organelles. When a variety of stimuli induce the aggregation of unfolded proteins in the endoplasmic reticulum, resulting in the imbalance of calcium ions and redox re...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/53G01N27/447A61B5/022
CPCG01N33/6893G01N33/53G01N27/44717A61B5/022A61B5/02233
Inventor 陈利国陈伟豪刘天浩方梅霞肖雅周永红何玲袁静许清芸陈旭东陶文聪
Owner JINAN UNIVERSITY
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