High-concentration sample identification method, device and detection system
An identification method and high-concentration technology, applied in the detection field, can solve problems such as deviation from reaction rate, reaction rate error, and extremely large reaction rate error, so as to achieve accurate identification results and improve reliability
Active Publication Date: 2022-03-15
MACCURA MEDICAL INSTR CO LTD
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However, this method directly uses two points to directly calculate the slope within the time period. If the original curve filtering effect is not good, it is very likely that the signal error at a certain point is large, which will lead to a large error in the reaction rate, so that deviation from the actual reaction rate
like figure 2 As shown, when the filtering effect is not good, there may still be V-shaped fluctuations. If the time point for calculating the slope falls on the fluctuation point, it will cause a large error in the calculated reaction rate. Based on these two points, the calculated The reaction rate value deviates from the true value of the actual reaction rate
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[0045]In view of the problems existing in the prior art, the inventors adopted a reaction kinetics method to verify the existence of excess antigen (ie, high-concentration sample) by analyzing the kinetic data obtained during sample measurement. In most cases, the kinetics of the reaction are dependent on the analyte concentration: low concentration samples can show increasing signal, while high concentration samples can show a more rapid signal increase at the beginning of the reaction and a much lower signal at the end of the reaction Increase, for high-concentration samples, there will be a violent reaction at the initial stage of the reaction between the sample and the reagent, which will cause a large degree of curvature in the response curve during this period. The inventors use this feature to utilize different curves The absorbance data sequence corresponding to the segment calculates the parameter value that can reflect the difference in curvature between the two ends ...
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The invention relates to a high-concentration sample identification method, device and detection system, wherein the high-concentration sample identification method includes: processing the original signal response data of the sample to obtain an absorbance change curve; A curve segment and a second curve segment, wherein the length of the data sequence corresponding to the first curve segment is equal to the length of the data sequence corresponding to the second curve segment; through the absorbance data sequence corresponding to the first curve segment and the absorbance corresponding to the second curve segment The data sequence calculates the first parameter value that can reflect the difference in curvature between the first curve segment and the second curve segment; by comparing the first parameter value with the judgment threshold R, it is judged whether the sample is a high-concentration sample. This method can eliminate the influence of some abnormal points with large fluctuations, and make the identification results of high-concentration samples more accurate.
Description
technical field [0001] The invention relates to the technical field of detection, in particular to a high-concentration sample identification method, device and detection system. Background technique [0002] In the field of medical testing, DD, FDP and other items in coagulation items are usually detected by turbidimetry. [0003] The detection principle of the turbidimetric method is: add the sample to be tested, such as plasma, into the cuvette for antigen-antibody reaction with the reaction reagent, irradiate one end of the cuvette with light generated by a light source, and use the other end of the cuvette to The receiver receives the transmitted light and converts it into a signal value. During the detection process, as the detected substance (antigen) in the plasma combines with the corresponding antibody to form an antigen-antibody complex, the light intensity of the transmitted light received will change to a certain extent, and then the unit time is calculated acc...
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IPC IPC(8): G01N21/31G01N21/82G01N33/86
CPCG01N21/31G01N21/82G01N33/86G01N2021/825
Inventor 王准赵清楠
Owner MACCURA MEDICAL INSTR CO LTD