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Traditional Chinese medicine composition for improving endometrial receptivity, and application of traditional Chinese medicine composition

A technology of endometrium and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, diseases, etc., to improve endometrial thickness and endometrial blood flow, improve endometrial receptivity, Effects on Improving Pregnancy Outcomes

Active Publication Date: 2019-12-20
天津中医药大学第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the deficiencies and defects of the medicines for treating endometrial receptivity in the prior art, the present invention provides a compound traditional Chinese medicine composition for treating endometrial receptivity, which has the functions of warming the kidney, invigorating the spleen, removing dampness The effect of turbidity, the effect of improving endometrial receptivity, and is a safe and effective pure Chinese medicine preparation

Method used

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  • Traditional Chinese medicine composition for improving endometrial receptivity, and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for improving endometrial receptivity, and application of traditional Chinese medicine composition

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Embodiment 1

[0026] From April 2018 to August 2019, 93 patients with poor endometrial receptivity and repeated implantation failure who visited the Reproductive Center of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine before frozen thawed embryotransfer (FET) were collected retrospectively. According to the clinical data, according to whether the method of warming the yang and transforming the turbidity was used, it was divided into a treatment group of 52 cases (5 cases of natural pregnancy, 47 cases actually entered the FET cycle), and a control group of 41 cases. The age of the treatment group was 33.53±4.32, the age of the control group was 32.17±5.23; the body mass index of the treatment group was (21.94±2.50) kg / m 2 , BMI of the control group (21.88±2.57) kg / m 2; The duration of infertility in the treatment group was 2 (1.5, 4) years, and the duration of infertility in the control group was 3 (1.5, 5) years; The number of embryos transferred was ...

Embodiment 2

[0063] Lu Mou, female, 30 years old, did not use contraception and did not conceive again for 2 years, IVF-ET transplantation failed 3 times, and spontaneous abortion 1 time. In December 2016, the patient failed to conceive after two stimulations. Due to unknown reasons, the patient voluntarily underwent IVF-ET. The specific plan is unknown. 12 eggs were retrieved, 6 embryos were formed, and 2 ETs. After 2 months of pregnancy, she spontaneously aborted without curettage. ; In May 2017, 2 FETs were not pregnant; in June 2017, 2 FETs were not pregnant; in December 2017, 11 eggs were retrieved, 6 embryos were formed, and 2 ETs were not pregnant. There are 4 frozen embryos. Usually, menstruation is early or late, the menstrual period is 7 days, the cycle is 25-33 days, the amount is heavy, the color is dark, blood clots (+), dysmenorrhea (+). The man's semen test was normal. The patient visited our hospital on March 23, 2018. The following symptoms were recorded: on the third da...

Embodiment 3

[0065]Miao, female, 37 years old, has not been pregnant for more than 7 years without contraception, and failed 5 times of IVF-FET. In 2005, due to right tubal ectopic pregnancy, right salpingectomy was performed, and in 2015, right ovarian teratoma was removed. In 2015, the natural cycle of B-ultrasound was used to monitor follicles for 3 cycles, showing dominant follicles, ovulation, hydrosalpinx in the left side of the fallopian tube, and regular sex life without re-pregnancy. Therefore, in December 2016, 18 eggs were retrieved due to gamete transport disorder, and 6 embryos were formed. In February, April, and September 2017, FETs were performed 3 times, but none of them became pregnant. In December 2017, 23 eggs and 10 embryos (including 4 blastocysts) were retrieved in the long-term plan. After the egg retrieval, laparoscopic left salpingectomy was performed in January 2018. Hormone replacement was performed in March and October 2018. Cycle FET twice, not pregnant. She...

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Abstract

The invention relates to a traditional Chinese medicine composition for improving endometrial receptivity. The traditional Chinese medicine composition comprises 15-25 parts of raw radix astragali, 25-35 parts of semen cuscutae, 15-25 parts of cornu cervi degelatinatum, 5-15 parts of herba cistanches, 5-15 parts of radix morindae officinalis, 10-20 parts of poria cocos, 5-15 parts of fried atractylodis macrocephalae rhizome, 3-8 parts of rhizoma atractylodis, 15-25 parts of fried coicis semen, 15-25 parts of semen plantaginis, 5-15 parts of citri reticulatae pericarpium, 5-15 parts of nymphaeaL. petiole, 5-15 parts of herba agastaches and 3-8 parts of phellodendri chinensis cortex. The invention provides the compound traditional Chinese medicine composition for treating the endometrial receptivity, and the traditional Chinese medicine composition has the functions of warming the kidney, strengthening the spleen, resolving dampness and eliminating turbidity, has an effect on improvingthe endometrial receptivity, and is a safe and effective pure traditional Chinese medicine preparation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for improving endometrial receptivity and an application thereof. Background technique [0002] Endometrial receptivity refers to the ability of the endometrium to allow blastocysts to locate, adhere, penetrate, implant, and implant the embryo. The main manifestations of endometrial receptivity are: endometrium is too thin, poor shape, uneven echo, insufficient blood supply, intrauterine adhesions, etc. Embryo implantation depends on the normally developed endometrium, and good endometrial receptivity is a necessary condition for pregnancy. [0003] Reproductive health is one of the core contents of my country's population health strategy, which is related to the success or failure of my country's economic and social sustainable development strategy. In recent years, the incidence of infertility has been increasing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P15/00A61K35/32
CPCA61K35/32A61K36/076A61K36/284A61K36/39A61K36/43A61K36/481A61K36/532A61K36/62A61K36/64A61K36/68A61K36/746A61K36/752A61K36/756A61K36/8994A61P15/00A61K2300/00
Inventor 夏天付于赵志梅马赛花窦真宋佳怡
Owner 天津中医药大学第一附属医院
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