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Application of triptonide

A technology of triptolide ketone and drugs, applied in the field of medicine, can solve the problems of increased hospitalization fatality rate and increased disability rate of stroke patients

Pending Publication Date: 2019-12-24
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the study found that non-diabetic ischemic stroke patients with blood glucose levels exceeding 6.0-8.0mmol / L increased the hospitalization mortality rate by 3 times, and increased the disability rate of stroke patients, suggesting that hyperglycemia may have a direct effect on ischemic brain tissue. Toxic effect

Method used

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  • Application of triptonide
  • Application of triptonide
  • Application of triptonide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Effect of triptolide ketone administration on blood sugar in ICR mice

[0024] (1) Experimental materials

[0025] (1) Experimental animals:

[0026] Strain: ICR mice, male and female;

[0027] Source: Experimental Animal Center of Soochow University School of Medicine;

[0028] Weight: 18-22g;

[0029] Number of animals in each group: 10.

[0030] (2) Mouse feed formula: maltodextrin (12%), sucrose (18%), cholesterol (2%), imported lard (21%), casein (21%), whole milk powder (5%) , Alfalfa Powder (3%), Corn Starch (8.5%), L-Cystine (0.5%), Vegetable Oil (3%), Premix (6%).

[0031] (3) Test drug: Triptolide was diluted with normal saline to the concentration required for the test.

[0032] (2) Experimental method

[0033] 30 ICR mice, weighing 18-22g. They were randomly divided into three groups, 10 rats in each group, half male and half male: high-fat diet group (HFD-TN), high-fat diet+triptolide treatment group (HFD+TN) and normal diet group (ND). ...

Embodiment 2

[0039] Example 2: The effect of triptolide ketone administration prevention on blood sugar in ICR mice

[0040] (1) Experimental materials

[0041] (1) Experimental animals:

[0042] Strain: ICR mice, male and female;

[0043] Source: Experimental Animal Center of Soochow University School of Medicine;

[0044] Weight: 18-22g;

[0045] Number of animals in each group: 10.

[0046](2) Mouse feed formula: maltodextrin (12%), sucrose (18%), cholesterol (2%), imported lard (21%), casein (21%), whole milk powder (5%) , Alfalfa Powder (3%), Corn Starch (8.5%), L-Cystine (0.5%), Vegetable Oil (3%), Premix (6%).

[0047] (3) Test drug: Triptolide was diluted with normal saline to the desired concentration.

[0048] (2) Experimental method

[0049] 20 ICR mice, weighing 18-22g. They were randomly divided into three groups, 10 rats in each group, half male and half male): high-fat diet group (HFD-TN), high-fat diet+triptolide treatment group (HFD+TN). The HFD-TN group and HFD+T...

Embodiment 3

[0055] Example 3: Effect of Triptolide Administration on Blood Glucose in C57-ApoE Knockout Mice

[0056] (1) Experimental materials

[0057] (1) Experimental animals:

[0058] Strain: C57-ApoE knockout mouse, male;

[0059] Source: Experimental Animal Center of Soochow University School of Medicine;

[0060] Weight: 18-25g;

[0061] Number of animals in each group: 10.

[0062] (2) Mouse feed formula: maltodextrin (12%), sucrose (18%), cholesterol (2%), imported lard (21%), casein (21%), whole milk powder (5%) , Alfalfa Powder (3%), Corn Starch (8.5%), L-Cystine (0.5%), Vegetable Oil (3%), Premix (6%).

[0063] (3) Test drug: Triptolide was diluted with normal saline to the desired concentration.

[0064] (2) Experimental method

[0065] 30 C57-ApoE knockout mice, weighing 18-25 g. They were randomly divided into three groups, 10 in each group, male mice: high-fat diet group (HFD-TN), high-fat diet+triptolide treatment group (HFD+TN) and normal diet group (ND). The H...

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Abstract

The invention relates to the technical field of medicines, and discloses an application of triptonide. The invention finds that the Chinese herbal medicine monomer triptonide can significantly reducethe blood glucose level of a high-fat diet obesity mouse after prevention or treatment administration, and can also reduce the blood glucose content of the C57-ApoE knocked-out high-fat diet obesity model mouse. The result shows that the triptonide has prevention and treatment effects on hyperglycemia. The hyperglycemia is the main cause of the hyperglycemia type diabetes, so that the triptonide can also be applied to the preparation of related medicines of the hyperglycemia type diabetes.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of triptolide. Background technique [0002] The sugar in the blood is called blood sugar, and in most cases it is glucose (Glucose). Most of the energy required for the activities of various tissue cells in the body comes from glucose, so blood sugar must be maintained at a certain level to maintain the needs of various organs and tissues in the body. The fasting blood glucose concentration of normal people is 3.6-6.2mmol / L. A fasting blood glucose concentration exceeding 7.0mmol / L is called hyperglycemia, and a blood glucose concentration below 3.6mmol / L is called hypoglycemia. [0003] Many factors can lead to hyperglycemia in critical illness. Hyperglycemia can cause fluid imbalance, reduce immune function and increase infection. In vitro experiments have demonstrated that hyperglycemia can lead to abnormal white blood cell function, and these abnormalitie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61P3/10
CPCA61K31/585A61P3/10
Inventor 周泉生曹志飞
Owner SUZHOU UNIV
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