Composition for increasing hair quantity in follicular unit and preparation method thereof

A composition and unit technology, applied in the directions of drug combinations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as the small number of hairs, and achieve the effects of promoting hair follicle health, improving oil environment, and promoting sustainable healthy growth.

Active Publication Date: 2021-10-08
天晴干细胞股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the problem that the amount of hair in the follicular unit is less after the use of the existing AGA treatment means, and provides a composition for increasing the amount of hair in the follicular unit and its preparation method

Method used

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  • Composition for increasing hair quantity in follicular unit and preparation method thereof
  • Composition for increasing hair quantity in follicular unit and preparation method thereof
  • Composition for increasing hair quantity in follicular unit and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0041]Embodiment 1: The composition for increasing the number of hairs in the follicular unit of this embodiment includes liquid A, liquid B, and liquid C; the volume ratio of liquid A, liquid B, and liquid C is (1-2):(0.5-1) :(7-8.5);

[0042] Liquid A is hair follicle telogen inhibitor, including lactic acid 0.1-10.0mg / ml, citric acid 0.1-1.5mg / ml, gluconic acid 1.0-4.4mg / ml, tryptophan 3-30μg / ml and deionized water ;

[0043] Liquid B is an inflammatory control agent, including interleukin-1 receptor antagonist IL-1ra 3.0-14.0ng / ml, soluble tumor necrosis factor receptor-1 10.0-30.0ng / ml and deionized water;

[0044] Liquid C is a hair growth promoter, that is, super active platelet lysate (sPL).

specific Embodiment approach 2

[0045] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the preparation method of the C liquid is:

[0046] A. Collect autologous blood, add anticoagulant to obtain anticoagulant blood, centrifuge at 20°C, 200g-250g for 10 minutes, remove the lower red blood cells; then mix the remaining blood in the centrifuge tube evenly, and then centrifuge at 22°C, 3000g After 15 minutes, the upper 4 / 5 plasma was removed, and the bottom 1 / 5 plasma was inverted and mixed to form concentrated platelet plasma;

[0047] B. Sonicate the concentrated platelet plasma obtained in step A in an ice bath for 10-15 minutes, and then bathe in liquid nitrogen for 1-2 hours to obtain a platelet plasma lysate;

[0048] C. Take the platelet lysate obtained in step B out of liquid nitrogen and resuscitate, then place it at 18-25°C for 4-6 hours,

[0049] D. Then add heparan sulfate, mix well at 4°C, so that the final concentration of heparan sulfate is 1-3U / ml...

specific Embodiment approach 3

[0057] Embodiment 3: The difference between this embodiment and Embodiment 2 is that the anticoagulant in step A is sodium citrate anticoagulant. Others are the same as in the second embodiment.

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Abstract

A composition for increasing the number of hairs in follicular units and a preparation method thereof, relating to a composition for increasing the number of hairs and a preparation method thereof. It is to solve the problem that the number of hairs in the follicular unit is less after the use of the existing AGA treatment medicine. The composition includes liquid A, liquid B and liquid C. Solution A includes lactic acid, citric acid, gluconic acid, tryptophan and deionized water; solution B includes interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor and deionized water; solution C is platelet lysate. Method: 1. Mix lactic acid, citric acid, gluconic acid, tryptophan and deionized water to prepare liquid A. 2. Mix interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor-1 and deionized Mixing with water to prepare liquid B, third, preparing liquid C, and fourth, uniformly mixing liquid A, liquid B and liquid C to obtain a composition for increasing the number of hairs in the follicular unit. The present invention is used to improve hair loss.

Description

technical field [0001] The invention relates to a composition for increasing hair count and a preparation method thereof. Background technique [0002] Hair is a special variant organ of the epidermal differentiation of the keratinized accessory structure of the skin. Hair mainly has the effect of protecting the body and beautifying people's appearance. Healthy hair can protect the human head from or reduce the damage of external machinery and germs, and can regulate body temperature. In summer, the hair can radiate heat to the body; in winter, the hair can keep the body at a certain temperature. There are about 100,000-150,000 hairs in a person, and the growth cycle of hair can be divided into rapid growth phase (anagen phase), degenerative phase (catagen phase) and resting phase (telogen phase). About 90% of the hair is in the growth phase, and the growth phase of a single hair can last for 2-7 years. 1% of the hair is in the catagen phase, and the maintenance time is 2...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/19A61K31/191A61K31/194A61K31/405A61K35/16A61K38/17A61P17/14
CPCA61K31/19A61K31/191A61K31/194A61K31/405A61K35/16A61K38/1793A61K45/06A61P17/14A61K2300/00
Inventor 张怡谢兴琴刘春香车彦川牛春玮刘艳青
Owner 天晴干细胞股份有限公司
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