Kit for detecting metabolism of aspirin and high reactivity of platelets and detection method

A technology of aspirin and high reactivity, which is applied in the field of biomedicine, can solve the problems of incomplete response and misleading, and achieve the effect of high sensitivity and poor reduction effect

Active Publication Date: 2020-01-10
湖南菲思特精准医疗科技有限公司
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Problems solved by technology

However, the drug metabolism disorder or genetic defect that leads to true aspirin "resistance" has not been clarified, and the statement of AR is somewhat misleading. Therefore, highon-aspirin platelet reactivity (HAPR) under aspirin treatment is currently used to describe this resistance. aspirin incomplete response state
Although there are differences in urinary 11dhTXB2 levels in different populations, the inhibition rate after aspirin application is similar, mostly 60%-80%

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  • Kit for detecting metabolism of aspirin and high reactivity of platelets and detection method
  • Kit for detecting metabolism of aspirin and high reactivity of platelets and detection method
  • Kit for detecting metabolism of aspirin and high reactivity of platelets and detection method

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Embodiment Construction

[0042] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, so that those skilled in the art can better understand the present invention and implement it, but the examples given are not intended to limit the present invention.

[0043] The experimental methods in the following examples are conventional methods unless otherwise specified. The experimental materials used in the following examples were purchased from the market unless otherwise specified.

[0044] The chemiluminescence detection method for the curative effect of aspirin disclosed in this embodiment is to detect the content of 11-DH-TXB2 in human urine by chemiluminescence. The chemiluminescence method in this example adopts the principle of the competition method, uses magnetic particles as the solid phase of the immune reaction, and uses the chemiluminescence immunoassay method to cooperate with the chemiluminescence detector to detect 11-d...

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Abstract

The invention belongs to the technical field of biomedicine and relates to a chemiluminiscence detection kit for detecting the metabolism of aspirin and the high reactivity of platelets and a detection method. The kit comprises an 11-dehydro-thromboxane B2 monoclonal antibody, an 11-dehydro-thromboxane B2 competitive product, magnetic particles and a luminous substrate; and whether a patient has drug resistance or resistance to aspirin can be detected through the detection kit. The detection method has the advantages of high sensitivity, high accuracy and little possibility of being influencedby biochemical indexes. The detection method provides a scientific reference basis for clinical administration and can be applied to clinical medication guidance. With the detection method adopted, the problem of the failure or poor effect of the antiplatelet aggregation treatment of a clinical patient caused by aspirin resistance of the clinical patient can be solved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a chemiluminescence detection kit and a detection method for aspirin metabolism and platelet hyperreactivity. Background technique [0002] Metabolism of Thromboxane A2 (TXA2) and Detection Significance of 11-Dehydrothromboxane B2 (11-DH-TXB2) [0003] 11-dehydro-thromboxane B2 (11-dehydro-thromboxaneB2, 11-DH-TXB2) is the terminal metabolite of thromboxane A2 (thromboxaneA2, TXA2), which is mainly excreted by the kidneys, and plays a role in hemostasis and the occurrence of cardiovascular diseases play an important role in both. Arachidonic acid generates prostaglandin H under the action of prostaglandin H synthase 1 and 2 (COX-1 and COX-2). Prostaglandin H is chemically unstable and can be converted into a variety of biologically active prostaglandins under the action of isomerase, including TXA2, prostacyclin I2, prostaglandin D2, prostaglandin E2, and prostaglandin F2α. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543G01N33/577G01N33/58
CPCG01N33/54326G01N33/577G01N33/581G01N33/9486
Inventor 李秀星刘丹
Owner 湖南菲思特精准医疗科技有限公司
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