35 results about "Prostaglandin f" patented technology

The present invention describes novel methods for using 9-deoxy-2′,9-α-methano-3-oxa-4,5,6-trinor-3,7-(1′,3′-interphenylene)-13,14-dihydro-prostaglandin F₁ (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and/or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

The present invention is a method of treating blepharospasm with a prostaglandin derivative, comprising the steps of (a) providing a predetermined amount of prostaglandin derivative; and (b) applying the prostaglandin derivative in a predetermined position. The prostaglandin derivative is preferably in the form of latanoprost wherein the chemical composition of latanoprost is a prostaglandin F.sub.2.alpha derivative which has the chemical name isopropyl-(Z)-7[(1R,2R,3R,5S)3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl I]cyclo-pentyl]-5-heptenoate. The dosage of the prostaglandin derivative is generally in the range of 1.5 ug to 4.5 ug which is equivalent to 1 to 3 drops aqueous solution for human eye

An embryo that is transferred into the uterus of a recipient female is protected from embryotoxic effects of prostaglandin F_2α by exposing the embryo to a prostaglandin antagonist.

The present invention relates to a process for preparing a prostaglandin derivative and an intermediate therefor. In accordance with the present invention, the prostaglandin F (PGF) derivative can be efficiently prepared with high purity by removing the protecting group of a protected prostaglandin E (PGE) derivative obtained from conjugate addition and then stereoselectively reducing the ketone group on the cyclopentanone ring of the PGE derivative.

The invention relates to a specific monoclonal antibody hybridoma cell strain WXX-2 of antiprostaglandin F2alpha and application thereof and belongs to the technical field of clinical detection. The specific monoclonal antibody hybridoma cell strain WXX-2 of antiprostaglandin F2alpha provided by the invention has been preserved in CGMCC with the preservation number of CGMCC No. 13087. The specific monoclonal antibody of antiprostaglandin F2alpha is secreted by the specific monoclonal antibody hybridoma cell strain WXX-2 of antiprostaglandin F2alpha. The hybridoma cell strain WXX-2 can secrete a monoclonal antibody which has relatively good specificity and relatively high sensitivity on prostaglandin F2alpha, and the 50% inhibition concentration IC50 on the prostaglandin F2alpha is 1.80 [mu]g/L. The specific monoclonal antibody can be used for specific detection of the prostaglandin F2alpha in clinical detection.

AKR1B1 (EC 1.1.1.21) is an aldose reductase that has mainly been associated with the polyol pathway, and more recently with lipid deperoxidation. We have discovered that the primary activity of this enzyme is rather a PGFS activity, catalyzing the transformation of PGH₂ into PGF_2α. AKR1B1 as a therapeutic target, and method for modulating its expression and activity are provided. Methods for regulating the expression and activity of PGF_2α are also provided.

Cutaneous ulcers and non-healing skin wounds are a route for infection and represent a source of significant morbidity and mortality for humans. The present disclosure provides methods and compositions for treating, healing or preventing cutaneous ulcers and non-healing cutaneous wounds via the topical application of an effective amount of a nitric oxide (NO)-donating prostaglandin F2-alpha (PGF2-alpha) analog directly to the affected ulcer or non-healing cutaneous wound of a human in need of such treatment

A convergent synthesis of the prostaglandin F_2α analogues, travoprost and bimatoprost, was developed employing Julia-Lythgoe olefination of the structurally advanced phenylsulfone with an enantiomerically pure aldehyde ω-chain synthon. The novel convergent strategy allows the synthesis of a whole series of prostaglandin analogues of high purity from a common and structurally advanced prostaglandin intermediate.

The invention discloses an application of citrus fruit volatile oil in preparation of food and medicine that regulate a human endocrine system and are used to treat hemorrhoid. The functional hemorrhoid can be treated by inhibiting the secretion of prostaglandin F2alpha, increasing the secretion of prostaglandin E2, reducing the expression level of inflammatory factors, improving the body's antioxidant capacity, adjusting the human endocrine system, and stimulating the hormone secretion of glands in the body to return to normal levels The product makes full use of the peel of citrus fruits, avoids waste of resources, and can effectively treat hemorrhoid without temporary eating a laxative to improve hemorrhoid.