Application of citrus fruit volatile oil to preparation of food and medicine for treating constipation and food and medicine prepared from citrus fruit volatile oil

A citrus, volatile oil technology, applied in applications, medical preparations containing active ingredients, food science, etc., can solve the problems of resource waste, waste, slow sales of bergamot, etc., to avoid waste, treat functional constipation, and improve constipation. Effect

Inactive Publication Date: 2019-12-06
河北成弘生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Laxatives cannot be taken for a long time and can only temporarily relieve constipation symptoms. Therefore, it is of great significance to develop products that can treat functional constipation and have no side effects
[0003] At present, the citrus plants bergamot and sweet orange are widely planted in my country. The output of bergamot in Jinhua, Zhejiang has reached an annual output of 400-500 tons, which is mainly used as bergamot bonsai and fresh fruit sales. It has not expanded, which has led to unsalable and waste of bergamot. Therefore, it is particularly important to develop more functions of bergamot and promote the development of deep processing of bergamot. At present, the output of sweet oranges in my country has reached 7 million tons, and the sweet oranges on the market It is mainly eaten as a fruit and prepared as orange juice. Most of the peels are discarded and not fully utilized, resulting in a great waste of resources and environmental pollution. Therefore, strengthening the intensive processing of sweet oranges can make full use of sweet orange resources and promote the development of sweet oranges. The continuous development of the industry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] This embodiment provides the citrus fruit volatile oil for the functional animal experiment verification of the treatment of functional constipation:

[0023] 1. Animals and grouping: 48 healthy SPF-grade KM mice weighing 25-35 g, half male and half male, were equally divided into three groups: blank group, model group, and experimental group. Measure the levels of prostaglandins, inflammatory factors, and antioxidant capacity.

[0024] 2. Model establishment: The mice in the model group and the experimental group were used for functional constipation modeling: the compound diphenoxylate suspension was administered orally with a dose of 10 mg / kg·d, and the volume of the intragastric administration was 0.1ml / 10g for 14 days ; Mice in the blank group were given 0.9% normal saline by intragastric administration with the same dose and capacity for 14 days. Activated carbon suspension was prepared, and mice were fasted for 12 hours after modeling, and activated carbon suspe...

Embodiment 2

[0041] This embodiment provides a method for preparing food and medicine prepared from citrus fruit volatile oil, comprising the following steps:

[0042] Step 1: Extraction of volatile oil: after cleaning the fresh citrus fruit, cut off the peel, cut the peel into small pieces of 8 mm × 8 mm × 8 mm, extract the volatile oil by steam distillation for 2 hours at a material-to-liquid ratio of 1:4, collect the volatile oil and Add anhydrous sodium sulfate for dehydration, and filter to obtain citrus fruit volatile oil. Preferably, the citrus fruit can be sweet orange, pomelo, grapefruit, tangerine or bergamot.

[0043]Step 2: After mixing the citrus fruit volatile oil and starch octenyl succinate solution in a mass ratio of 1:4, high-speed shearing at 4000r / min, homogenization at 25MPa, and preparation of citrus fruits by spray drying Volatile oil powder grease, spray drying conditions are inlet air temperature 190°C, outlet air temperature 90-100°C, sample injection speed 30mL / ...

Embodiment 3

[0052] The present embodiment provides a method for preparing capsules containing citrus fruit volatile oil, comprising the following steps:

[0053] Step 1: Extraction of volatile oil: fresh citrus fruits, cut off the peel, cut the peel into small pieces of 8mm×8mm×8mm, extract by steam distillation for 2 hours at a material-liquid ratio of 1:4, collect the volatile oil and add Dehydrated with sodium sulfate, filtered to obtain citrus fruit volatile oil.

[0054] Step 2: After mixing the citrus fruit volatile oil and starch octenyl succinate solution in a mass ratio of 1:4, high-speed shearing at 4000r / min, homogenization at 25MPa, and preparation of citrus fruits by spray drying Volatile oil powder grease, spray drying conditions are inlet air temperature 190°C, outlet air temperature 90-100°C, sample injection speed 30mL / min, centrifugal atomizer speed 20000r / min.

[0055] Step 2: Glycerin, gelatin and water are made into capsule skins by conventional pharmaceutical method...

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PUM

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Abstract

The invention discloses application of citrus fruit volatile oil to preparation of food and medicine for regulating a human endocrine system and treating functional constipation. By inhibiting the secretion of prostaglandin F2[alpha], improving the secretion of prostaglandin E2, lowering the expression level of inflammatory factors and improving the antioxidant capacity of an organism, the human endocrine system is regulated, hormone secretion of glands in the body is stimulated to return to a normal level, and thus the functional constipation is treated. The peels of citrus fruits are fully utilized, the waste of resources is avoided, the functional constipation can be effectively treated, and people do not need to temporarily eat laxative to relieve the constipation.

Description

technical field [0001] The invention relates to the application of citrus fruit volatile oil in the preparation of food and medicine for treating constipation and the prepared food and medicine. Background technique [0002] Functional constipation is one of the common digestive system diseases in clinical practice. The 2016 Rome IV diagnostic criteria defined it as spontaneous defecation times less than 3 times per week, hard feces or dry fecal balls, strenuous defecation, irregular defecation, etc. Sensation of fullness, feeling of anorectal obstruction or blockage during defecation, need for manual assistance in defecation, at least 2 items, and no anatomical, neurological, or metabolic abnormalities. The incidence of functional constipation in infants and young children in my country accounts for more than 20% of pediatric gastrointestinal disease outpatient clinics, and the incidence of functional constipation in adults in my country is about 4%-6%. rate as high as 22%....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P5/00A61P1/10A23D9/007A23D9/02
CPCA23D9/007A23D9/02A61K36/752A61P1/10A61P5/00
Inventor 常瑞欣吴逸群杨达
Owner 河北成弘生物科技有限公司
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