Application of neuroprotective effect of asperosaponin VI to treatment of depression
A technology of saponin and neuroprotection, applied in the application field of neuroprotection in the treatment of depression, to achieve the effects of protecting neurogenesis, inhibiting the activation of microglia and central inflammatory response
Pending Publication Date: 2020-01-17
贵州中医药大学
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Problems solved by technology
Numerous studies have led us to believe that inflammation is an important cause of depression, however many questions remain to be answered if inflammatory processes do play an important role in the pathogenesis and pathology of depression
Method used
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Experimental program
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Effect test
Embodiment 1
[0054] Example 1: Dipsacus saponin VI was taken as the crude drug, and 1 / 20 of the starch was added, and granulated to obtain granules.
Embodiment 2
[0055] Example 2: Take Dipsacus saponin VI as the bulk drug, add 1 / 20 of the starch, mix well, put it into capsules, and obtain capsules.
Embodiment 3
[0056] Example 3: Take Dipsacus saponin VI as the bulk drug, add 1 / 20 of dextrin, mix evenly, dry, and make a pill.
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The invention relates to application of a neuroprotective effect of asperosaponin VI to treatment of depression. The asperosaponin VI serves as a main active component of a Chinese herbal medicine, namely teasel, and has good pharmacological activity in the aspects such as neuroprotection and myocardial protection, the nerve injury caused by neuroinflammation is considered as one of disease causesof depression, and thus exploration of the neuroprotective effect of the asperosaponin VI on treatment of depression has the wide development prospects.
Description
technical field [0001] The invention relates to the field of drug application, in particular to the application of the neuroprotective effect of Dipsacus saponin VI in the treatment of depression. Background technique [0002] Depression (Depression) is a kind of disease with depressed mood as the main performance, usually manifested as mood disorder, characterized by low mood, lack of interest or fun, and persistent fatigue, with high recurrence rate, high disability rate, high The characteristics of suicide rate, low recognition rate, low visit rate, and low treatment rate predict that by 2020, depression will become the second largest disability factor that threatens human health after cancer. Therefore, the treatment and prevention of depression It is very important to improve people's health and quality of life. [0003] The cause of depression: ① From the perspective of traditional Chinese medicine, it is believed that liver qi deficiency, that is, the yang qi in the ...
Claims
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IPC IPC(8): A61K31/704A61P25/24A61P25/00
CPCA61K31/704A61P25/24A61P25/00
Inventor 张进强周涛江维克郭兰萍肖承鸿
Owner 贵州中医药大学