Construction and application of a guinea pig animal model infected with Streptococcus suis type 9

A technology of Streptococcus suis and animal models, which is applied in the field of vaccine and drug development and evaluation research, can solve the problems of inability to carry out SS9 pathogenicity, infection mechanism vaccine and drug development and evaluation research work, and lack, etc., to achieve easy operation and feeding Convenient and repeatable effect

Active Publication Date: 2022-04-05
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there are domestic and foreign animal models using mice, rabbits, guinea pigs, and zebrafish to study SS2 infection, there is a lack of animal models for SS9 infection, and it is impossible to carry out research on SS9 pathogenicity, infection mechanism, vaccine and drug development and evaluation

Method used

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  • Construction and application of a guinea pig animal model infected with Streptococcus suis type 9
  • Construction and application of a guinea pig animal model infected with Streptococcus suis type 9

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Experimental program
Comparison scheme
Effect test

Embodiment

[0024] The present invention provides a kind of construction of Streptococcus suis type 9 infection guinea pig animal model, wherein the steps of construction:

[0025] S1. Animal preparation for inoculation: select guinea pigs aged 4-6 weeks, and divide them into normal control group (n=6), PBS control group (n=6) and 6 experimental groups (n=6×6), in the same environment Breed in groups for 5-7 days. Guinea pigs are used as a substitute for piglets. They are small in size and easy to raise. The length and weight of each group of guinea pigs should be roughly the same, and they should be raised in a simulated ecological environment. On the one hand, it can ensure that they are in the same environment In the living environment, the interference of external factors on the experimental data is avoided. On the other hand, the guinea pigs of each group are fed uniformly in a simulated ecological way, which can avoid the interference of different environments and eating on the exper...

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PUM

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Abstract

The invention discloses the construction and application of a guinea pig animal model infected with Streptococcus suis type 9, and specifically relates to the field of vaccine and drug development and evaluation research, wherein the construction steps include preparation of inoculated animals, preparation of bacterial solution, animal inoculation, clinical observation and Anatomical identification. The guinea pig model of the present invention is convenient to raise, easy to operate, can strongly show the typical clinical symptoms and pathological changes of SS9 infection, is similar to the natural infection of piglets, and has good repeatability; a guinea pig animal model infected with Streptococcus suis type 9 is constructed, which can be used In the research work of SS9 pathogenicity, infection mechanism, vaccine and drug development and evaluation.

Description

technical field [0001] The invention relates to the technical field of vaccine and drug development and evaluation research, more specifically, the invention relates to the construction and application of a guinea pig animal model infected with Streptococcus suis type 9. Background technique [0002] Streptococcus suis (SS) is an important zoonotic pathogen, belonging to the genus Streptococcus. The colonization site of Streptococcus suis is the upper respiratory tract of pigs, especially the tonsils and nasal cavity. Some serotypes of Streptococcus suis are pathogenic and can cause acute sepsis, meningitis, arthritis, endocarditis, pneumonia and other diseases in pigs. Some strains can cause human infection, causing bacterial meningitis or toxic shock-like syndrome. SS is a worldwide epidemic, which poses a major threat to the pig industry and public health safety. According to the characteristics of the capsular antigen, according to the difference of its capsular antig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K67/02
CPCA01K67/02A01K2227/105A01K2267/0337
Inventor 蔡汝健李春玲杨冬霞楚品品宋帅勾红潮蒋智勇李艳
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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