FMT image-forming principle-based method for detecting in vivo characteristics of small animals
A technology based on feature detection and imaging principles, applied in diagnostic recording/measurement, medical science, diagnosis using tomography, etc. It can solve the problems of inability to quantify signals at different depths and quantitative detection of small animals, and achieve accurate and effective quantitative detection , the effect of improving the accuracy
Inactive Publication Date: 2020-01-24
窦少彬
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[0006] Aiming at the above-mentioned shortcomings in the prior art, the present invention provides a small animal living feature detection method based on the principle of FMT imaging, which can effectively overcome the inability to quantitatively detect small animals in the prior art, and for different depth positions. Defects where the signal cannot be quantified
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[0033] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention are clearly and completely described below. Apparently, the described embodiments are some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.
[0034] A small animal living feature detection method based on the principle of FMT imaging, comprising the following steps:
[0035] S1. Optically mark the small animals of the research object;
[0036] S2. Observation of deep optical marker signals in small animals using laser bottom-through excitation;
[0037] S3. Using laser bottom penetration scanning and ultrasonic depth positioning to obtain optical marker signals at different fau...
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The invention relates to in vivo imaging of small animals and particularly relates to an FMT image-forming principle-based method for detecting in vivo characteristics of small animals. The method comprises the following steps: performing optical marking on a small animal serving as a study object; observing a deep optical mark signal in the small animal body by adopting laser clear-bottom excitation; acquiring optical mark signals at different fault depths in the small animal body by utilizing laser clear-bottom scanning and ultrasonic depth localization; obtaining three-dimensional quantitative information of the optical mark signals by combining a 3D reconstruction analysis algorithm; and performing combined use with other imaging systems by means of an imaging mode adaptor. According to the technical scheme, the defects in the prior art that small animals cannot be subjected to quantitative detection, and signals at different depth positions cannot be quantified can be effectivelyovercome.
Description
technical field [0001] The invention relates to live imaging of small animals, in particular to a method for detecting live features of small animals based on the principle of FMT imaging. Background technique [0002] Small animal in vivo optical imaging technology has been around for nearly 10 years, and has been applied to research in many fields such as biology and medicine. However, with the deepening of various researches, the traditional small animal in vivo imaging system has been unable to meet the research needs in many aspects, mainly in the following aspects: 1. Observation of deep signals cannot be realized; 2. Absolutely accurate quantification cannot be performed; 3. Obtain real 3D reconstruction information; 4. It cannot be used in conjunction with other molecular imaging systems (such as CT, PET, MRI, etc.). [0003] One of the technical bottlenecks of the existing in vivo optical imaging systems is the quantitative problem. At present, all quantitative met...
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IPC IPC(8): A61B5/00
CPCA61B5/0062A61B5/0073A61B5/0075A61B2503/40
Inventor 窦少彬
Owner 窦少彬