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An anti-blocking and anti-infection shunt tube and its preparation method

A shunt tube and anti-infection technology, which is applied in catheters, anticoagulant treatment, packaging food, etc., can solve the problem of composite coating shunt tubes that have not been seen yet, and achieve the effect of preventing shunt tube infection and reducing infection

Active Publication Date: 2022-05-17
XIAN HONGHUI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the main problem facing anticoagulation and antibacterial shunt tube coating technology is: how to make the coating at the liquid-solid interface achieve the expected anti-clogging and anti-infection effects for the flowing liquid environment in the shunt tube, that is, the composition of the coating There is no clear basis for selection
At the same time, at present, there is no report on the use of sodium citrate and chymotrypsin to make composite coating shunt tubes.

Method used

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  • An anti-blocking and anti-infection shunt tube and its preparation method
  • An anti-blocking and anti-infection shunt tube and its preparation method
  • An anti-blocking and anti-infection shunt tube and its preparation method

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Embodiment Construction

[0024] The present invention will be described in further detail below in conjunction with the examples.

[0025] (1) Design of shunt tube coating

[0026] Through model experiments and clinical data analysis, the present invention finds that the main reason for the blockage of the shunt tube is the aggregation of red blood cells, the adhesion of white blood cells, and the accumulation of proteins, which lead to the gradual narrowing of the shunt tube until it is blocked. The action of most cell adhesion molecules (CAM) depends on divalent cations, such as Ca 2+ , Mg 2+ . There are three modes of action of cell adhesion molecules: mutual recognition and binding between the same CAM molecules on the surface of two adjacent cells (homophilic adhesion); mutual recognition and binding between different CAM molecules on the surface of two adjacent cells (heterophilic adhesion); the same CAM molecules on the surface of two adjacent cells recognize and bind to each other through e...

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Abstract

The invention discloses an anti-blocking and anti-infection shunt tube and a preparation method thereof: the shunt tube includes a composite coating of sodium citrate and chymotrypsin and a super deep coating, which can effectively prevent blood clots, white blood cells and protein sticking in the shunt tube. It can also prevent the infection of the shunt tube and effectively avoid the danger caused by frequent replacement of the shunt tube.

Description

technical field [0001] The invention relates to a medical instrument for hydrocephalus shunt, in particular to an anti-blocking and anti-infection shunt tube. Background technique [0002] Since Kausch first applied ventricular-peritoneal shunt (V-P shunt) to treat hydrocephalus, along with the development of shunt, the shunt device in V-P shunt has been continuously improved, and the shunt technology has also been continuously improved to minimize the risk of shunt. complication. Nevertheless, complications from various shunt failures continue to arise, making it the greatest obstacle in the treatment of hydrocephalus. Some scholars reviewed the history of shunt surgery and pointed out that the failure rate of shunt surgery was 40% in 1 year and 50% in 2 years. The most common causes of shunt failure are shunt blockage, shunt infection, and excessive shunt, among which shunt blockage ranks first, and shunt infection can be life-threatening. [0003] Clinically, the only ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/08A61L29/16A61L33/16A61M25/00
CPCA61L29/08A61L29/085A61L29/16A61L33/0047A61L33/12A61L33/0094A61M25/0045A61M25/0009A61M2025/0056A61L2300/216A61L2300/406A61L2300/254A61L2300/42A61L2420/02A61L2420/06A61L2420/08C08L89/00
Inventor 赵东升别小华
Owner XIAN HONGHUI HOSPITAL