Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition, preparation method and application thereof in treatment of ischemic stroke

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of large dosage, poor quality controllability, and poor preparation performance of patients, and achieve high curative effect, good stability, and solubility Good results

Inactive Publication Date: 2020-01-31
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] However, the preparation methods of traditional Chinese medicine are mostly mixed and decocted medicinal materials, and the active ingredients are not clear; most of them are process control, but the quality controllability is poor; the drug solubility is poor, the preparation performance is poor, the patient takes a large amount of medicine, and the compliance is not good

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition, preparation method and application thereof in treatment of ischemic stroke
  • Pharmaceutical composition, preparation method and application thereof in treatment of ischemic stroke
  • Pharmaceutical composition, preparation method and application thereof in treatment of ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Take 18.4g of safflower, pulverize it, and extract twice with 10 times of water for 2 hours each time; the extracts are combined and concentrated to about 180ml. 200g of D101 type macroporous adsorption resin was loaded into the column, and the sample was loaded. Wash 1.3 L with water at a flow rate of 2 BV / h, and discard the washing solution; elute with 450 ml of 50% ethanol at a flow rate of 2 BV / h; collect the eluate, concentrate, and dry to obtain the safflower extract.

[0095] Take 52.5g of kudzu root, grind it, and extract it twice with 8 times 95% ethanol for 2 hours each time; the extracts are combined and concentrated until there is no alcohol smell, and then diluted with water to about 52ml. 130g of AB-8 macroporous adsorption resin was packed into the column, and the sample was loaded. Wash with 520ml of water at a flow rate of 2BV / h, and discard the washing solution; elute with 650ml of 70% ethanol at a flow rate of 2BV / h; collect the eluent, concentrate, ...

Embodiment 2

[0100] Take 1.84 kg of safflower, crush it, extract it twice with 12 times and 11 times water, each time for 2 hours; the extracts are combined and concentrated to about 1.8L. D101 type macroporous adsorption resin 20kg packed column, loading sample. Wash 130L with water at a flow rate of 2BV / h, and discard the washing solution; elute with 45L of 50% ethanol at a flow rate of 2BV / h; collect the eluate, concentrate, and dry to obtain the safflower extract.

[0101] Take 5.13 kg of Pueraria root, crush it, and extract it twice with 8 times 95% ethanol for 2 hours each time; the extracts are combined and concentrated until there is no alcohol smell, and then diluted with water to about 5.1 L. 12.8 kg of AB-8 macroporous adsorption resin was packed into the column, and the sample was loaded. Wash 50L with water at a flow rate of 2BV / h, and discard the washing solution; elute with 64L of 70% ethanol at a flow rate of 2BV / h; collect the eluent, concentrate, and dry to obtain the ku...

Embodiment 3

[0106] Take 184g of safflower, pulverize, extract twice with 12 times and 11 times water, each time for 2 hours; the extracts are combined and concentrated to about 180ml. D101 type macroporous adsorption resin 2kg packed column, loading sample. Wash 13L with water at a flow rate of 2BV / h, and discard the washing solution; elute with 4.5L of 50% ethanol at a flow rate of 2BV / h; collect the eluate, concentrate, and dry to obtain the safflower extract.

[0107] Take 371g of kudzu root, crush it, extract it twice with 10 times and 9 times 95% ethanol, each time for 2 hours; the extracts are combined and concentrated until there is no alcohol smell, and diluted with water to about 740ml. Pack 900g of AB-8 macroporous resin into the column and load the sample. Wash 3.6L with 5% ethanol at a flow rate of 2BV / h, and discard the eluate; elute with 4.5L of 70% ethanol at a flow rate of 2BV / h; collect the eluate, concentrate, and dry to obtain the kudzu root extract.

[0108] Take 156...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a pharmaceutical composition and application thereof in preparing a medicament for treating stroke. The pharmaceutical composition consists of the following raw materials in parts by weight: panax notoginseng saponins 1-5 parts, safflower flower extract 10-30 parts, kudzuvine root extract 15-60 parts, ligusticum wallichii extract 10-40 parts, and hawthorn fruit extract 20-45 parts. The pharmaceutical composition is prepared by respectively subjecting safflower flower, kudzuvine root, ligusticum wallichii and hawthorn fruit to extracting, performing separating and purifying to obtain corresponding extracts, and uniformly mixing the extracts with the panax notoginseng saponins. The pharmaceutical composition has excellent solubility and drug-forming properties, is easy to absorb and has rapid onset of action.

Description

technical field [0001] The invention relates to a formulation of a pharmaceutical composition and a preparation method thereof. The invention also relates to its application in the preparation of medicine for treating ischemic stroke. Background technique [0002] "China Stroke Prevention Report (2017)" shows that in 2016, cardiovascular and cerebrovascular diseases caused more than 17.6 million deaths worldwide, while the incidence of stroke in my country has been rising and younger. In the past two decades, the prevalence rate has increased. to 1.23%, the recurrence rate in the first year was 17%, and the cumulative recurrence rate in 5 years was >30%. Stroke has become the leading cause of death among Chinese residents, and the death toll is 4-5 times higher than that in Europe and the United States. The mortality rate of ischemic stroke, which accounts for 60%-80% of stroke types, has increased by 28.8%. [0003] The pathogenic factors and pathophysiological mechanis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61P9/10
CPCA61K36/258A61K36/286A61K36/488A61K36/236A61K36/734A61P9/10A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P25/00A61K2300/00
Inventor 屈晶朱海波普盼盼渠凯程妍杨柳
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com