Preparation method of 2-pyrrolidone derivative

A technology of pyrrolidone and derivatives, which is applied in the field of preparation of 2-pyrrolidone derivatives and achieves the effect of adapting to a wide range
CN110759847AActive Publication Date: 2020-02-07NINGBO UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NINGBO UNIV
Publication Date
2020-02-07

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Abstract

The invention relates to a preparation method of a 2-pyrrolidone derivative. According to the method, 1,6-eneyne compounds, carbonyl compounds, oxidizing agents and organic solvent are added into a Schlenk reaction flask, the mixture is stirred on the conditions of certain temperature and the air atmosphere to carry out free radical cyclization reaction.
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Description

technical field

[0001] The application belongs to the field of organic synthesis, and in particular relates to a preparation method of 2-pyrrolidone derivatives. Background technique

[0002] Radical cyclizations of enynes have gradually emerged as a straightforward and highly step-economical strategy for the construction of complex cyclic compounds. In recent years, transition metal-catalyzed reaction systems have been rapidly developed and widely used in this type of reaction. However, the use of transition metal catalysts not only increases the reaction cost, but also leaves metal residues in the product, which limits its further application in biochemistry. Therefore, it is of great scientific and practical significance to develop the radical cyclization reactions of enynes in metal-free systems.

[0003] Carbonyl compound C(sp 2 The oxidative functionalization of )-H bonds has become an important method for the rapid introduction of carbonyl groups in modern syntheti...

Claims

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