Method for preparing multichannel antibacterial nerve conduits by adopting variable spindle knitting way

Abstract

The invention relates to a method for preparing multichannel antibacterial nerve conduits by adopting a variable spindle knitting way. The method for preparing the multichannel antibacterial nerve conduits by adopting the variable spindle knitting way comprises the following steps: knitting multiple inner tube braiding yarns outside an inner core filling material so as to form a conduit, wherein the conduit comprises an inner core filling material and a tube body with which the outer side of the inner core filling material is sleeved, colors of the inner tube braiding yarns and the inner corefilling material are significantly different, the inner core filling material is a solid cylinder with a smooth surface, and number of the inner tube braiding yarns can be estimated by a formula as follows in which m represents number of the inner tube braiding yarns, dy represents diameters of the inner tube braiding yarns, R represents internal diameter of an external conduit, n represents number of internal conduits, r represents internal radii of the internal conduits, kappa is larger than 0 and smaller than or equal to 1 and lambda is larger than 0 and smaller than or equal to 1; dividingthe conduits into n tubes, arranging the n tubes in parallel so as to be used as a core material; knitting the inner tube braiding yarns outside the core material so as to form the external conduit outside the core material; and then, removing the inner core filling material so as to obtain a multichannel antibacterial nerve conduit.

Description

technical field [0001] The invention relates to a preparation method of a nerve guide, in particular to a method for preparing a multi-channel antibacterial nerve guide by a variable spindle braiding method. Background technique [0002] Nerve injury is a difficult problem in medical treatment at present. When the distance of nerve defect is relatively large, the standard clinical practice is to use autologous nerve transplantation. However, there are many problems in autologous nerve transplantation. First, the nerve donor site will face functional or sensory impairment caused by secondary injury and nerve defect in the donor area; second, the size of different types of nerve fibers varies greatly, resulting in mismatch. The allogeneic nerve transplantation will appear immune rejection. Therefore, for long-distance nerve defects, people have been looking for reliable methods and ideal materials to prepare artificial nerve conduits for nerve repair to replace autologous ner...

AI Technical Summary

Problems solved by technology

[0005] In summary, most of the current technologies for preparing artificial nerve conduits with microporous channels are limited to the use of electrospinning and mold methods, or a combination of these two methods

The common disadvantages of the nerve guides prepared by these methods are poor repeatability of sample preparation, large batch-to-batch variance, and poor mechanical properties.

The spun membrane made by electrospinning has poor operability and is easy to deform and tear during the preparation of nerve conduits

The catheters made by the mold method often use the method of solvent volatilization and chemical cross-linking. The prepared catheters may have the problem of toxicity of the cross-linking agent. If genipin is used as the cross-linking agent, although the toxicity is not high, the cost is too high

If no cross-linking agent is used, the mechanical properties of the catheter are not ideal

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